Prof. Jiguang Wang
Assistant Professor | Lab Page at HKUST | 中文网页 | Email: jgwang-at-ust.hk
Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
Jiguang Wang was born in Cangxian Hebei, China. He got his Ph.D. degree from AMSS of CAS in July 2011, and now is working at Hong Kong University of Sciecne and Technology as an Assistant Professor.
Opening positions in Hong Kong University of Science and Technology.Experience
- 2016-now Assistant Professor, Hong Kong University of Science and Technology
- 2015-2016 Associate Research Scientist, Columbia University
- 2011-2011 Visiting Scholar, University of Missouri
- 2011-2013 Research Assistant Professor, Beijing Institute of Genomics
Training and Education
- 2011-2015 Postdoctoral Research Scientist, Columbia University
- 2006-2011 PhD in Applied Mathematics, AMSS, CAS
- 2006-2011 Visiting Students, Shanghai Institute for Biological Sciences
- 2002-2006 ScB in Applied Mathematics, Beijing Institute of Technology
Research Interests
- Precision Medicine
- Cancer Genomics and Next Generation Sequencing
- Transcriptome Assembly and Non-coding RNAs
- Network Biology and Systems Biology
- Operations Reseach
- Machine Learning
Research Projects
- 2015- Topology of Cancer Evolution and Heterogeneity, Co-Investigator, NCI-U54
- 2014-2018 Provocative Questions: Reconstruction of Evolutionary Networks using Cross-Sectional Genomic Data, Co-Investigator, NCI-R01
- 2009-2010 The research of dynamic model and algorithms for network biomarkers in type 2 diabetes, Principal Investigator, Ph. D research project supported by Chinese Academy of Sciences
Awards and Honors
- 2014 Travel Fellowship of 10th International Symposium on Bioinformatics Research and Applications
- 2007 Merit Student in AMSS
- 2006 Beijing Outstanding Graduates and Admission with waiver of postgraduate entrance examination
- 2005 Honorable Prize in Mathematical Contest in Modeling and Second class Prize in CUMCM
- 2004 Second class Prize in CUMCM
- 2002 First class Prize in Chinese Mathematical Olympiad and Admission with waiver of national college admission examination
Selected Publications
Google Citation | ResearcherID:B-2717-2012 | ResearchGate
Clonal Evolution of Glioblastoma under Therapy.
Jiguang Wang, Emanuela Cazzato, Erik Ladewig, Veronique Frattini, Daniel I. S. Rosenbloom, Sakellarios Zairis, Francesco Abate, Zhaoqi Liu, Oliver Elliott, Yong-Jae Shin, Jin-Ku Lee, In-Hee Lee, Woong-Yang Park, Marica Eoli, Andrew Blumberg, Anna Lasorella, Do-Hyun Nam#, Gaetano Finocchiaro#, Antonio Iavarone#, Raul Rabadan#.
Nature Genetics, 48, 768–776, 2016.
Kenta Yamamoto, Jiguang Wang, Lisa Sprinzen, Jun Xu, Christopher J. Haddock, Chen Li, Brian J. Lee, Denis G. Loredan, Wenxia Jiang, Alessandro Vindigni, Dong Wang, Raul Rabadan and Shan Zha.
eLife, 10.7554/eLife.14709, 2016.
RNA-Exosome-Regulated Long Non-coding RNA Transcription Controls Super-Enhancer Activity.
Evangelos Pefanis*, Jiguang Wang*, Gerson Rothschild*, Junghyun Lim*, Kazadi D, Sun J, Federation A, Chao J, Elliott O, Liu ZP, Economides AN, Bradner JE, Rabadan R, Basu U.
Cell, Volume 161, Issue 4, p774–789, 7 May 2015. (*First authors) EXOTOME browser
Jiguang Wang#, Hossein Khiabanian, Davide Rossi, Giulia Fabbri, Valter Gattei, Francesco Forconi, Luca Laurenti, Roberto Marasca, Giovanni Del Poeta, Robin Foà, Laura Pasqualucci, Gianluca Gaidano, Raul Rabadan#.
Evangelos Pefanis*, Jiguang Wang*, Gerson Rothschild*, Junghyun Lim, Jaime Chao, Raul Rabadan, Aris N. Economides, Uttiya Basu
Nature, 514(7522), 389–393, doi:10.1038/nature13580, 2014. (* co-first authors).
:::This paper has been evaluated by F1000:::
:::This paper has been evaluated by F1000:::
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
Michele Ceccarelli, Floris P Barthel, Tathiane M Malta, Thais S Sabedot, Sofie R Salama, Bradley A Murray, Olena Morozova, Yulia Newton, Amie Radenbaugh, Stefano M Pagnotta, Samreen Anjum, Jiguang Wang, Ganiraju Manyam, Pietro Zoppoli, Shiyun Ling, Arjun A Rao, Mia Grifford, Andrew D Cherniack, Hailei Zhang, Laila Poisson, Carlos Gilberto Carlotti, Daniela Pretti da Cunha Tirapelli, Arvind Rao, Tom Mikkelsen, Ching C Lau, WK Alfred Yung, Raul Rabadan, Jason Huse, Daniel J Brat, Norman L Lehman, Jill S Barnholtz-Sloan, Siyuan Zheng, Kenneth Hess, Ganesh Rao, Matthew Meyerson, Rameen Beroukhim, Lee Cooper, Rehan Akbani, Margaret Wrensch, David Haussler, Kenneth D Aldape, Peter W Laird, David H Gutmann, TCGA Research Network, Houtan Noushmehr, Antonio Iavarone, Roel GW Verhaak.
Cell, Volume 164, Issue 3, 550-563, 2016.
Transcriptomics identify CD9 as a marker of murine IL10-competent regulatory B cells.
Jianbo Sun, Jiguang Wang, Evangelos Pefanis, Jaime Chao, Gerson Rothschild, Isao Tachibana, Jun Kui Chen, Ivaylo I. Ivanov, Raul Rabadan, Yoshito Takeda, Uttiya Basu
Cell Reports, Volume 13, Issue 6, p1110–1117, 10 November 2015.
NOA: a novel Network Ontology Analysis method.
Jiguang Wang, Qiang Huang, Zhi-Ping Liu, Yong Wang, Ling-Yun Wu, Luonan Chen, Xiang-Sun Zhang.
Nucleic Acids Research, doi: 10.1093/nar/gkr251, 2011.
Disease-aging network reveals significant roles of aging genes in connecting genetic diseases.
Jiguang Wang, Shihua Zhang, Yong Wang, Luonan Chen, and Xiang-Sun Zhang.
Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes.
M Messina*, S Chiaretti*, Jiguang Wang*, AL Fedullo, N Peragine, V Gianfelici, A Piciocchi, F Brugnoletti, F Di Giacomo, S Pauselli, AB Holmes, MC Puzzolo, G Ceglie, V Apicella, M Mancini, G Te Kronnie, AM Testi, A Vitale, M Vignetti, A Guarini, R Rabadan, R Foà.
Network stratification analysis for identifying function-specific network layers.
C Zhang*, Jiguang Wang*, C Zhang, J Liu, D Xu, L Chen.
Molecular BioSystems, 12(4):1232-40, 2016.
Ilaria Del Giudice*, Marilisa Marinelli*, Jiguang Wang*, Silvia Bonina, Monica Messina, Sabina Chiaretti, Caterina Ilari, Luciana Cafforio, Sara Raponi, Francesca R. Mauro, Valeria Di Maio, Maria S. De Propris, Mauro Nanni, Carmela Ciardullo, Davide Rossi, Gianluca Gaidano, Anna Guarini, Raul Rabadan and Robin Foà.
British Journal of Haematology, DOI: 10.1111/bjh.13859, 2015. (* co-first authors).
An information theoretic method to identify combinations of genomic alterations that promote glioblastoma.
Rachel D. Melamed, Jiguang Wang, Antonio Iavarone and Raul Rabadan.
J Mol Cell Biol, doi: 10.1093/jmcb/mjv026, 2015.
Network propagation reveals novel genetic features predicting drug response of cancer cell lines.
Jiguang Wang*, Judith Kribelbauer*, Raul Rabadan.
Current Bioinformatics, Volume 11, issue 5, 2016.
The research on molecular network models of complex disease (in Chinese)
Sci Sin Math, 44(4): 317-328, doi: 10.1360/012013-143, 2014.
Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia
D Rossi, H Khiabanian, V Spina, C Ciardullo, A Bruscaggin, R Famà, Silvia Rasi, Sara Monti, Clara Deambrogi, Lorenzo De Paoli, Jiguang Wang, Valter Gattei, Anna Guarini, Robin Foà, Raul Rabadan, and Gianluca Gaidano
Blood, blood-2013-11-539726, 2014.
PU. 1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway
J Zhou, J Wu, B Li, D Liu, J Yu, X Yan, S Zheng, J Wang, L Zhang, L Zhang, F He, Q Li, A Chen, Y Zhang, X Zhao, Y Guan, X Zhao, J Yan, J Ni, M A Nobrega, B Löwenberg, R Delwel, P J M Valk, A Kumar, L Xie, D G Tenen, G Huang and Q-f Wang
Leukemia, doi: 10.1038/leu.2013.384, 2014.
Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome.
Giulia Fabbri, Hossein Khiabanian, Antony B Holmes, Jiguang Wang, Monica Messina, Charles G Mullighan, Laura Pasqualucci, Raul Rabadan, Riccardo Dalla-Favera
Journal of Experimental Medicine, 10/2013; DOI:10.1084/jem.20131448, 2013.
E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells.
Jianbo Sun, Celia D. Keim, Jiguang Wang, David Kazadi, Paula M. Oliver, Raul Rabadan and Uttiya Basu
Genes & Dev., 27: 1821-1833, 2013.
B cell development and IL-10 secretion.
Uttiya Basu, Jianbo Sun, and Jiguang Wang
The Journal of Immunology, 190, 174.23, 2013.
NOA: A Cytoscape Plugin for Network Ontology Analysis.
Chao Zhang*, Jiguang Wang*, Kristina Hanspers, Dong Xu, Luonan Chen, Alexander R. Pico.
Bioinformatics, 29 (16): 2066-2067, 2013. (* co-first authors)
APG: an Active Protein-Gene Network Model to Quantify Regulatory Signals in Complex Biological Systems.
Jiguang Wang, Yidan Sun, Si Zheng, Xiang-Sun Zhang, Hua-Rong Zhou, Luonan Chen.
Scientific Reports, 3 : 1097, DOI: 10.1038/srep01097, 2013.
Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis.
Wei Song*, Jiguang Wang*, Ying Yang, Nai-He Jing, Xiang-Sun Zhang, Luonan Chen, Jia-Rui Wu
Journal of Molecular Cell Biology 4(3), doi: 10.1093/jmcb/mjs029, 2012 (* co-first authors).
Whole-exome Sequencing Reveals Recurrent Somatic Mutation Networks in Cancer.
Xiaoping Liu*, Jiguang Wang*, Luonan Chen.
Cancer Letters, 2012 (* co-first authors).
The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development.
Davide Rossi, Vladimir Trifonov, Marco Fangazio, Alessio Bruscaggin, Silvia Rasi, Valeria Spina, Sara Monti, Tiziana Vaisitti, Francesca Arruga, Rosella Famà, Carmela Ciardullo, Mariangela Greco, Stefania Cresta, Daniela Piranda, Antony Holmes, Giulia Fabbri, Monica Messina, Andrea Rinaldi, Jiguang Wang, Claudio Agostinelli, Pier Paolo Piccaluga, Marco Lucioni, Fabrizio Tabbò, Roberto Serra, Silvia Franceschetti, Clara Deambrogi, Giulia Daniele, Valter Gattei, Roberto Marasca, Fabio Facchetti, Luca Arcaini, Giorgio Inghirami, Francesco Bertoni, Stefano A Pileri, Silvia Deaglio, Robin Foà, Riccardo Dalla-Favera, Laura Pasqualucci, Raul Rabadan, Gianluca Gaidano.
The Journal of Experimental Medicine , 209(9): 1537-1551, 2012.
Modularity optimization in community detection of complex networks.
Xiang-Sun Zhang, Rui-Sheng Wang, Yong Wang, Jiguang Wang, Yu-Qing Qiu, Lin Wang, and Luonan Chen.
Europhysics Letters, 87: 38002, 2009.
Remarks on network community properties
Jiguang Wang, Yuqing Qiu, Rui-Sheng Wang, Xiang-Sun Zhang.
Jrl Syst Sci & Complexity, 21: 637-644, 2008.
Books
- Contribution to Encyclopedia of Systems Biology: Clustering methods, Co-expression, Edge ontology, Functional enrichment analysis, Gene ontology, Ontology analysis of biological networks, Partial correlation coefficient, Pearson correlation coefficient, Time-delay correlation
Links
- EXOTOME browser | NOA Manual Page in NRNB | NOA Cytoscape Plug-in in Cytoscape App Store | NOA Webserver
- Columbia University | University of Missouri | Beijing Institute of Genomics | Academy of Mathematics & Systems Science | Beijing Institute of Technology | Cangzhou secondary high school
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