Ruisheng Wang
王瑞省
Department of Medicine, Brigham and Women's Hospital & Harvard Medical SchoolAddress: 77 avenue louis pasteur, NRB 631, Boston, MA 02115
Tel: 1-617-525-4834
Email: rwang@research.bwh.harvard.edu
Research/Professional positions
- 08/2013 - present, Research associate at Department of Medicine, Brigham and Women's Hospital, Harvard Medical School
- 08/2008 - 07/2013, Postdoctoral Research Fellow at Department of Physics, Pennsylvania State University
- 08/2005 - 07/2008, Assistant Professor at School of Information, Renmin University of China
- 10/2006 - 03/2008, Visiting Intelligent Information Lab, Osaka Sangyo University
Educational Background
- 09/2002 - 07/2005, Ph.D. in Operation Research and Control theory, Academy of Mathematics & Systems Science, CAS.
- 09/1999 - 07/2002, M.S. in Applied Mathematics, College of Mathematics & Computer Sciences, Hebei University.
- 09/1995 - 07/1999, B.S. in Applied Mathematics, Department of Mathematics, Hebei University.
Research Interests
- Systems biology/Computational biology
- Biological network inference, analysis, and modeling
- Therapeutic target discovery in disease networks
- Highthroughput transcriptome/metabolome analysis
- Tag SNP/Haplotype inference and disease association
- Complex networks
- Structure and dynamics of complex networks
- Graph/Optimization theory and application
Publications
- A.M. Jones, Y. Xuan, M. Xu, R.S. Wang, C.H. Ho, S. Lalonde, C.H. You, M.I. Sardi, S.A. Parsa, E. Smith-Valle, et al
Border Control—A Membrane-Linked Interactome of Arabidopsis
Science, 344(6185),711-716, 2014 PDF
- X. Jin, R.S. Wang, M. Zhu, B.W. Jeon, R. Albert, S. Chen, S.M. Assmann
Abscisic Acid–Responsive Guard Cell Metabolomes of Arabidopsis Wild-Type and gpa1 G-Protein Mutants
The Plant Cell, 25, 4789-4811 2013 PDF
- R.S. Wang, R. Albert
Effects of community structure on the dynamics of random threshold networks
Physical Review E, 87 (1), 012810, 2013 PDF
- R.S. Wang, Z. Sun, R. Albert
Minimal functional routes in directed graphs with dependent edges
International Transactions in Operational Research, 20(3), 391-409, 2013 PDF
- R.S. Wang, A. Saadatpour, R. Albert
Boolean modeling in systems biology: an overview of methodology and applications
Physical Biology, 9(5), 055001, 2012 PDF
- X.S. Zhang, Z. Li, R.S. Wang, Y. Wang
A combinatorial model and algorithm for globally searching community structure in complex networks
Journal of Combinatorial Optimization, 23, 425–442, 2012 PDF
- A. Saadatpour, R.S. Wang, A. Liao, X. Liu, T.P. Loughran, I. Albert, R. Albert
Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia
PLOS Computational Biology, 7(11): e102267, 2011 PDF
- Z. Li, R.S. Wang, X.S. Zhang
Two-stage flux balance analysis of metabolic networks for drug target identification
BMC systems biology, 5 (Suppl 1), S11, 2011 PDF
- R.S. Wang, R. Albert
Elementary signaling modes predict the essentiality of signal transduction network components
BMC Systems Biology, 5:44, 2011PDF
- R.S. Wang, S. Pandey, S. Li, T. Gookin, Z. Zhao, R. Albert, S.M. Assmann
Common and unique elements of the ABA-regulated transcriptome of Arabidopsis guard cells
BMC Genomics, 12:216, 2011 PDF
- S. Pandey*, R.S. Wang*, L. Wilson, S. Li, Z. Zhao, T. Gookin, S.M. Assmann, R. Albert
Boolean modeling of transcriptome data reveals novel modes of heterotrimeric G protein action
Molecular Systems Biology, 6:372, 2010 (* Joint first authors)PDF
- R. Albert, R.S. Wang
Discrete dynamic modeling of cellular signaling networks
Methods in Enzymology, 467, 281-306, 2009 PDF
- R.S. Wang, G. Jin, X.S. Zhang, L. Chen
Modeling post-transcriptional regulation activity of small non-coding RNAs in Escherichia coli
BMC Bioinformatics, 10(suppl4):S6, 2009 PDF
- Z. Li, R.S. Wang, X.S. Zhang, L. Chen
Detecting drug targets with minimum side effects in metabolic networks
IET Systems Biology, 3(6), 523-533, 2009 PDF
- X.S. Zhang, R.S. Wang, Y. Wang, J. Wang, Q. Qiu, L. Wang, L. Chen
Modularity optimization in community detection of complex networks
Europhysics Letters, 87, 38002, 2009 PDF
- X.M. Zhao, R.S. Wang, L. Chen, K. Aihara
Automatic modeling of signaling pathways by network flow model
Journal of Bioinformatics and Computational Biology, 7(2),309-322, 2009 PDF
- R.S. Wang, S. Zhang, Y. Wang, X.S. Zhang, L. Chen
Clustering complex networks and biological networks by Nonnegative Matrix Factorization with various similarity measures
Neurocomputing, 72, 134-141, 2008. PDF
- R.S. Wang, M.H. Ha
On the properties of sequences of fuzzy-valued Choquet integrable function
Fuzzy Optimization and Decision Making, 7(4), 417-431, 2008 PDF
- X.M. Zhao, R.S. Wang, L. Chen, K. Aihara
Uncovering signal transduction networks from high-throughput data by integer linear programming
Nucleic Acids Research, 36, e48, 2008 PDF
- Z. Li, S. Zhang, R.S. Wang, X.S. Zhang and L. Chen
Quantitative function for community detection
Physical Review E, 77, 036109, 2008 PDF
- R.S. Wang, Y. Wang, L.Y. Wu, X.S. Zhang, L. Chen
Analysis on multi-domain cooperation for predicting protein-protein interactions
BMC Bioinformatics, 8:391, 2007 PDF
- R.S. Wang, X.S. Zhang, L. Chen
Inferring transcriptional interactions and regulator activities from experimental data
Molecules and Cells, 24(3), 307-315, 2007 PDF
- R.S. Wang, Y. Wang, X.S. Zhang, L. Chen
Inferring transcriptional regulatory networks from high-throughput data
Bioinformatics, 23, 3056-3064, 2007 PDF
- S. Zhang, R.S. Wang, X.S. Zhang
Uncovering fuzzy community structure in complex networks
Physical Review E, 76, 046103, 2007 PDF
- S. Zhang, R.S. Wang, X.S. Zhang
Identification of overlapping community structure in complex networks using fuzzy c-means clustering
Physica A, 374, 483–490, 2007 PDF
- X.S. Zhang, R.S. Wang, L.Y. Wu, W. Zhang
Minimum conflict individual haplotyping from SNP fragments and related genotype
Evolutionary Bioinformatics, 2, 271-280, 2006 PDF
- X.S. Zhang, R.S. Wang, L.Y. Wu, L. Chen
Models and algorithms for the haplotyping problem
Current Bioinformatics, 1(1), 105-114, 2006 PDF
- R.S. Wang, L.M. Wang, M.H. Ha
Choquet integrals on L-fuzzy sets
The Journal of Fuzzy Mathematics, 14(1), 151-164, 2006 PDF
- R.S. Wang, L.Y. Wu, X.S. Zhang, L. Chen
A Markov chain model for haplotype assembly from SNP fragments
Genome Informatics, 17(2), 162-171, 2006 PDF
- R.S. Wang, L.Y. Wu, Z. Li, X.S. Zhang
Haplotype reconstruction from SNP fragments by minimum error correction
Bioinformatics, 21(10), pp: 2456-2462, 2005 PDF
Books
- L. Chen, R.S. Wang, X.S. Zhang
Biomolecular Networks: Methods and Applications in Systems Biology
John Wiley & Sons, Hoboken, NJ, 2009 LINK
Research Grants
- Several Fundamental Problems in Complex Networks (2007.1-2007.12)
- Research Foundation of Renmin University of China, Grant No. 06XNB054, Principal Investigator
- Research on theory and algorithms of community detection in complex networks (2008.1-2010.12)
- National Natural Science Foundation of China (NSFC), Grant No. 10701080, Principal Investigator
Quotations
- All models are wrong, but some are useful
George E.P. Box
- Everything should be made as simple as possible, but not simpler
Albert Einstein
- Nothing in biology makes sense except in the light of evolution
T. Dobzhansky.
