""Guangxujin"" ===**Guangxu Jin, Ph.D.**=== Assistant Professor, Wake Forest School of Medicine, Department of Radiology, Wake Forest Baptist Medical Center Comprehensive cancer center, Wake Forest Baptist Medical Center MRI 2nd FL Medical Center Blvd Winston-Salem, NC 27157 Office: +1 (336)716-6977 Cell: +1 (281)627-1455 ==**Education & Training**== ||2012.10 ~ 2014.2||Instructor and Research Associate|| [[http://www.methodisthealth.com/tmhri.cfm?id=39162 The Methodist Hospital Research Institute & Weill Cornell Medical College]]|| ||2008.10 ~ 2012.9||Postdoctoral Fellow|| [[http://www.methodisthealth.com/tmhri.cfm?id=39162 The Methodist Hospital Research Institute & Weill Cornell Medical College]]|| ||2007.12 ~ 2008.10||Exchange Student|| [[http://www.methodisthealth.com/tmhri.cfm?id=39162 The Methodist Hospital Research Institute & Weill Cornell Medical College]]|| ||2005.9 ~ 2008.7||Ph.D., Bioinformatics||[[http://www.amss.ac.cn/amss/amsscn.html Academy of Mathematics & Systems Science, CAS]]|| ||2002.9 ~ 2005.7||M.S., Operational Research||[[http://www.synu.edu.cn/synuen/p1.html Shenyang Normal University]] || ||1998.9 ~ 2002.7||B.S., Applied Mathematics||[[http://www.synu.edu.cn/synuen/p1.html Shenyang Normal University]] || ==**Professional Memberships**== American Association Cancer Research Member, 2011.2 - present Comprehensive cancer center, Wake Forest Baptist Medical Center Member, 2015.8 - present ==**Research Interests**== Cancer genomics, bioinformatics modeling Tumor recurrence is a major issue for many cancer types, such as glioblastoma multiforme (GBM) patients after receiving Temador treatments. However, the related molecular biology is not easy to be understood. It is because of the complexity of transcriptional events, which may be a mixture of epigenetic regulation and genetic control on function regions (e.g., enhancers and promoters). Recurrence or drug resistance is stage-specific. My research interest is in the patient-specific analysis by considering the variations from transcriptional, epigentic, and genetic variations. By applying to different stages of a patient, the failure of treatment can be explained by the identified comprehensive mechanisms, such as the regulation of a methylation on a new gene isoform or a function lost caused by a mutation in the CDS. The identified epigenetic regulation and genetic variation will be validated by CRISPR and TALE-TET1 genome editing techniques. ==**Selected Publications**== **Research Articles** ~1) L Liu, G Jin*, X Zhou* (2015) ---**[[http://nar.oxfordjournals.org/content/43/8/3873.short Modeling the relationship of epigenetic modifications to transcription factor binding]]**--- //Nucleic acids research// 43 (8), 3873-3885. *co-corresponding author ~1) Choi DS, Blanco E, Kim YS, Rodriguez AA, Zhao H, Huang TH, Chen CL, __Jin G__, Landis MD, Burey LA, Qian W, Granados SM, Dave B, Wong HH, Ferrari M, Wong ST, Chang JC. (2014) ---**[[http://www.ncbi.nlm.nih.gov/pubmed/24809620 Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1.]]**--- //Stem cells//. doi: 10.1002/stem.1746. ~1) __Guangxu Jin__ and Stephen T.C. Wong (2014) //Invited review//---**[[http://www.degruyter.com/view/j/itit.2014.56.issue-2/itit-2013-1019/itit-2013-1019.xml Enhanced Petri Net: Elucidating the Pathway-Level Mechanism of Targeted-Therapy Drugs]]**--- //Information Technology//. **56**(2): 67-75. ~1) __Guangxu Jin__ and Stephen T.C. Wong (2014) //Invited review//---**[[http://www.sciencedirect.com/science/article/pii/S1359644613003991 Toward better drug repositioning: Prioritizing and integrating existing methods into efficient pipelines]]**--- //Drug Discovery Today//. **19**(5); 637-644. ~1) Timothy Liu, Ding Ren, Xiaoping Zhu, Zheng Yin, __Guangxu Jin__, Zhen Zhao, Daniel Robinson, Xuping Li, Kelvin Wong, Kemi Cui, Hong Zhao, Stephen TC Wong (2013) ---**[[http://www.nature.com/srep/2013/131210/srep03467/pdf/srep03467.pdf Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform]]**--- //Scientific Report// **3**: 3467. ~1) Changhe Fu*, __Guangxu Jin*__, Junfeng Gao, Rui Zhu, Efren Ballesteros villagrana, Stephen T.C. Wong (2013) ---**[[http://r2d2drug.org/DMC.aspx DrugMap Central (DMC), an on-line query and visualization tool to facilitate drug repositioning studies]]**.--- //Bioinformatics//. 15;29(14):1834-6. *Co-first author. ""GuangxuJin"" ~1) Hong Zhao*, __Guangxu Jin*__, Kemi Cui , Ding Ren , Timothy Liu , Peikai Chen , Solomon Wong , Fuhai Li , Yubo Fan , Angel A. Rodriguez , Jenny C. Chang, Stephen T.C. Wong (2013) ---**[[http://cancerres.aacrjournals.org/content/early/2013/10/04/0008-5472.CAN-12-4617.long Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases]]**.--- //Cancer Research//, DOI: 10.1158/0008-5472.CAN-12-4617. *Co-first author. **//Cover paper and cover image//**. ~1) Fuhai Li, Zheng Yin, __Guangxu Jin__, Hong Zhao, Stephen Wong (2013) ---**[[http://www.ploscompbiol.org/article/authors/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003043;jsessionid=8DFC6E59E35277FA3339D30F435E6036 Bioimage Informatics for Systems Pharmacology]]**.--- //PLoS Comput Biol// **9**, e1003043. ~1) Wang, L., Zhao, H., Cui, K., Yao, L., Ren, M., Hao, A., Smollen, P., Nie, F., __Jin, G.__, Liu, Q. et al. (2012) ---**[[http://www.biosciencetrends.com/getabstract.php?id=586 Identification of novel small-molecule inhibitors of glioblastoma cell growth and invasion by high-throughput screening.]]** ---//Bioscience trends//, **6**, 192-200. ~1) Wang, L., Liu, Q., Zhao, H., Cui, K., Yao, L., Nie, F., __Jin, G.__, Hao, A. and Wong, S.T. (2013) ---**[[http://onlinelibrary.wiley.com/doi/10.1002/jnr.23140/abstract;jsessionid=EDD72B5DD57AB02C81C52084DC5BE4BC.d02t01 Differential effects of low- and high-dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion.]]**--- //Journal of neuroscience research//, **91**, 128-137. ~1) Fu, C., Deng, S., Jing, L., and __Jin, G.__ (2012) ---**[[http://ieeexplore.ieee.org/xpls/abs_all.jsp?tp=&arnumber=6314147&tag=1 Idenfication of Oncogenic Genes for Colon Adenocarcinoma from Genomics Data.]]**--- //IEEE systems biology//, **6**:263-266. ~1) __Guangxu Jin__, Changhe Fu, Hong Zhao, Kemi Cui, Jenny Chang, Stephen T.C. Wong --- **[[http://cancerres.aacrjournals.org/content/72/1/33.abstract A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy.]] **--- //Cancer Res//, 72:33-44, 2012. ~1) __Guangxu Jin__, Hong Zhao, Xiaobo Zhou, Stephen T.C. Wong --- **[[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117391/?tool=pubmed An enhanced Petri-net model to predict synergistic effects of pairwise drug combinations from gene microarray data.]] **--- //Bioinformatics//, 27(13):i310-6, 2011. ~1) Zhao H, Cui K, Nie F, Wang L, Brandl MB, __Jin G__, Li F, Mao Y, Xue Z, Rodriguez A, et al., ---**[[http://www.springerlink.com/content/a7514m4030782g38/ The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models.]]**--- //Breast Cancer Res Treat.// 2011 ~1) __Jin G__, Cui K, Zhou X, Wong ST --- **[[http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=5230853&tag=1 Unraveling the signal-transduction networks in cancer metastasis.]] **--- //IEEE Signal Proc Mag //**26**: 129-132, 2009. ~1) __Jin G__, Zhou X, Cui K, Zhang XS, Chen L, Wong ST --- **[[http://ieeexplore.ieee.org/Xplore/login.jsp?url=http%3A%2F%2Fieeexplore.ieee.org%2Fiel5%2F4100185%2F5344672%2F05344680.pdf%3Farnumber%3D5344680&authDecision=-203 A cross-platform method for identifying candidate network biomarkers for prostate cancer.]] **--- //IET Syst Biol //**3**(6), 505-512, 2009. ~1) Wang RS, __Jin G__, Zhang XS, Chen L --- **[[http://www.biomedcentral.com/1471-2105/10/S4/S6 Modeling post-transcriptional regulation activity of small non-coding RNAs in Escherichia coli.]]**--- //BMC Bioinformatics //**10 Suppl 4**: S6, 2009. ~1) __Jin G__, Zhou X, Wang H, Zhao H, Cui K, Zhang XS, Chen L, Hazen SL, Li K, Wong ST --- **[[http://pubs.acs.org/cgi-bin/abstract.cgi/jprobs/2008/7/i09/abs/pr8002886.html The Knowledge-Integrated network biomarkers discovery for major adverse cardiac events.]]**--- //J Proteome Res //**7**(9): 4013-4021, 2008. ~1) __Jin G__, Zhang S, Zhang XS, Chen L ---**[[http://www.plosone.org/article/fetchArticle.action?articleURI=info:doi/10.1371/journal.pone.0001207 Hubs with network motifs organize modularity dynamically in the protein-protein interaction network of yeast.]]**--- //PLoS ONE //**2**(11): e1207, 2007. ~1) Zhang S, __Jin G__, Zhang XS, Chen L (2007) ---**[[http://www3.interscience.wiley.com/journal/115804878/abstract?CRETRY=1&SRETRY=0 Discovering functions and revealing mechanisms at molecular level from biological networks.]]**--- //Proteomics// **7**(16): 2856-2869, 2007. **Book Chapters** ~1)__Jin G__, Wong ST ---**Proteomics Based Theranostics**--- //Cancer Theranostics//, Elsevier, 2014. ~1)__Jin G__, //Encyclopedia of Systems Biology//, Springer, New York, 2013 --- Chapters: [[http://link.springer.com/referenceworkentry/10.1007/978-1-4419-9863-7_464 Single-Input Module (1954-1954)]], [[http://link.springer.com/referenceworkentry/10.1007/978-1-4419-9863-7_465 Dense Overlapping Regulons (560-560)]], [[http://scholar.google.com/citations?view_op=view_citation&hl=en&user=3LUD1f0AAAAJ&sortby=pubdate&citation_for_view=3LUD1f0AAAAJ:tYavs44e6CUC Feed Forward Loop (737-738)]], [[http://link.springer.com/referenceworkentry/10.1007/978-1-4419-9863-7_590 Network Topology Motif (1523-1524)]], [[http://link.springer.com/referenceworkentry/10.1007/978-1-4419-9863-7_459 Network Motifs of Gene Regulatory Networks (1521-1523)]]--- ~1)__Jin G__, Zhou X, Wang H, Wong ST ---**[[http://www.springerlink.com/content/nv12843n3t20p766/ The challenges in blood proteomic biomarker discovery.]]**--- //Applied Bioinformatics and Biostatistics in Cancer Research//, Springer-Verlag New York Chapter **12**, 2010. **Patent** ~1)Wong ST, Zhao H, __Jin G__ (2012) ---**[[http://www.google.com/patents/US20120296090 Drug Repositioning Methods For Targeting Breast Tumor Initiating Cells.]]**--- //US Patent// 20,120,296,090 **database** - [[http://r2d2drug.org/DMC.aspx http://r2d2drug.org/DMC.aspx]] Last updated: 08/11/15