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""<img src="images/users/wangrs.jpg" alt="Rui-Sheng Wang" style="float: left; margin: 1.0%; padding: 0.5%;">""

====== Ruisheng Wang ======

====== 王瑞省======
Department of Medicine, Brigham and Women's Hospital & Harvard Medical School
''Address:'' 77 avenue louis pasteur, NRB 631, Boston, MA 02115
''Tel:'' 1-617-525-4834

=== Research/Professional positions ===

~-08/2013 - present, Research associate at Department of Medicine, [[ Brigham and Women's Hospital]], [[ Harvard Medical School]]
~-08/2008 - 07/2013, Postdoctoral Research Fellow at Department of Physics, [[ Pennsylvania State University]]
~-08/2005 - 07/2008, Assistant Professor at School of Information, [[ Renmin University of China]]
~~& 10/2006 - 03/2008, Visiting Intelligent Information Lab, [[ Osaka Sangyo University]]

===Educational Background===

~- 09/2002 - 07/2005, Ph.D. in Operation Research and Control theory, [[ Academy of Mathematics & Systems Science, CAS.]]
~- 09/1999 - 07/2002, M.S. in Applied Mathematics, [[ College of Mathematics & Computer Sciences, Hebei University.]]
~- 09/1995 - 07/1999, B.S. in Applied Mathematics, Department of Mathematics, [[ Hebei University.]]

===Research Interests===

~-Systems biology/Computational biology
~~&Biological network inference, analysis, and modeling
~~&Therapeutic target discovery in disease networks
~~&Highthroughput transcriptome/metabolome analysis
~~&Tag SNP/Haplotype inference and disease association
~-Complex networks
~~&Structure and dynamics of complex networks
~-Graph/Optimization theory and application


~[[ Google Scholar]] | [[ PubMed]]

~-A.M. Jones, Y. Xuan, M. Xu, R.S. Wang, C.H. Ho, S. Lalonde, C.H. You, M.I. Sardi, S.A. Parsa, E. Smith-Valle, et al---**Border Control—A Membrane-Linked Interactome of Arabidopsis**---//Science//, 344(6185),711-716, 2014 [[ PDF]]
~- X. Jin, R.S. Wang, M. Zhu, B.W. Jeon, R. Albert, S. Chen, S.M. Assmann---**Abscisic Acid–Responsive Guard Cell Metabolomes of Arabidopsis Wild-Type and gpa1 G-Protein Mutants**---//The Plant Cell//, 25, 4789-4811 2013 [[ PDF]]
~- R.S. Wang, R. Albert---**Effects of community structure on the dynamics of random threshold networks**---//Physical Review E//, 87 (1), 012810, 2013 [[ PDF]]
~- R.S. Wang, Z. Sun, R. Albert---**Minimal functional routes in directed graphs with dependent edges**---//International Transactions in Operational Research//, 20(3), 391-409, 2013 [[;jsessionid=E4550DC44613F135CB0904A25FD5EFB4.f02t02?deniedAccessCustomisedMessage=&userIsAuthenticated=false PDF]]
~- R.S. Wang, A. Saadatpour, R. Albert---**Boolean modeling in systems biology: an overview of methodology and applications**---//Physical Biology//, 9(5), 055001, 2012 [[ PDF]]
~- X.S. Zhang, Z. Li, R.S. Wang, Y. Wang---**A combinatorial model and algorithm for globally searching community structure in complex networks**---//Journal of Combinatorial Optimization//, 23, 425–442, 2012 [[ PDF]]
~-A. Saadatpour, R.S. Wang, A. Liao, X. Liu, T.P. Loughran, I. Albert, R. Albert---**Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia**---//PLOS Computational Biology//, 7(11): e102267, 2011 [[ PDF]]
~-Z. Li, R.S. Wang, X.S. Zhang---**Two-stage flux balance analysis of metabolic networks for drug target identification**---//BMC systems biology//, 5 (Suppl 1), S11, 2011 [[ PDF]]
~-R.S. Wang, R. Albert---**Elementary signaling modes predict the essentiality of signal transduction network components**---//BMC Systems Biology//, 5:44, 2011[[ PDF]]
~-R.S. Wang, S. Pandey, S. Li, T. Gookin, Z. Zhao, R. Albert, S.M. Assmann---**Common and unique elements of the ABA-regulated transcriptome of Arabidopsis guard cells**---//BMC Genomics//, 12:216, 2011 [[ PDF]]
~-S. Pandey*, R.S. Wang*, L. Wilson, S. Li, Z. Zhao, T. Gookin, S.M. Assmann, R. Albert---**Boolean modeling of transcriptome data reveals novel modes of heterotrimeric G protein action**---//Molecular Systems Biology//, 6:372, 2010 (* Joint first authors)[[ PDF]]
~-R. Albert, R.S. Wang---**Discrete dynamic modeling of cellular signaling networks**---//Methods in Enzymology//, 467, 281-306, 2009 [[ PDF]]
~-R.S. Wang, G. Jin, X.S. Zhang, L. Chen---**Modeling post-transcriptional regulation activity of small non-coding RNAs in Escherichia coli**---//BMC Bioinformatics//, 10(suppl4):S6, 2009 [[ PDF]]
~-Z. Li, R.S. Wang, X.S. Zhang, L. Chen---**Detecting drug targets with minimum side effects in metabolic networks**---//IET Systems Biology//, 3(6), 523-533, 2009 [[ PDF]]
~-X.S. Zhang, R.S. Wang, Y. Wang, J. Wang, Q. Qiu, L. Wang, L. Chen---**Modularity optimization in community detection of complex networks**---//Europhysics Letters//, 87, 38002, 2009 [[ PDF]]
~-X.M. Zhao, R.S. Wang, L. Chen, K. Aihara---**Automatic modeling of signaling pathways by network flow model**---//Journal of Bioinformatics and Computational Biology//, 7(2),309-322, 2009 [[ PDF]]
~- R.S. Wang, S. Zhang, Y. Wang, X.S. Zhang, L. Chen---**Clustering complex networks and biological networks by Nonnegative Matrix Factorization with various similarity measures**---//Neurocomputing,// 72, 134-141, 2008. [[ PDF]]
~- R.S. Wang, M.H. Ha---**On the properties of sequences of fuzzy-valued Choquet integrable function**---//Fuzzy Optimization and Decision Making//, 7(4), 417-431, 2008 [[ PDF]]
~-X.M. Zhao, R.S. Wang, L. Chen, K. Aihara---**Uncovering signal transduction networks from high-throughput data by integer linear programming**---//Nucleic Acids Research//, 36, e48, 2008 [[ PDF]]
~-Z. Li, S. Zhang, R.S. Wang, X.S. Zhang and L. Chen---**Quantitative function for community detection**---//Physical Review E//, 77, 036109, 2008 [[ PDF]]
~-R.S. Wang, Y. Wang, L.Y. Wu, X.S. Zhang, L. Chen---**Analysis on multi-domain cooperation for predicting protein-protein interactions**---//BMC Bioinformatics//, 8:391, 2007 [[ PDF]]
~-R.S. Wang, X.S. Zhang, L. Chen---**Inferring transcriptional interactions and regulator activities from experimental data**---//Molecules and Cells//, 24(3), 307-315, 2007 [[ PDF]]
~-R.S. Wang, Y. Wang, X.S. Zhang, L. Chen---**Inferring transcriptional regulatory networks from high-throughput data**---//Bioinformatics//, 23, 3056-3064, 2007 [[ PDF]]
~-S. Zhang, R.S. Wang, X.S. Zhang---**Uncovering fuzzy community structure in complex networks**---//Physical Review E//, 76, 046103, 2007 [[ PDF]]
~-S. Zhang, R.S. Wang, X.S. Zhang---**Identification of overlapping community structure in complex networks using fuzzy c-means clustering**---//Physica A//, 374, 483–490, 2007 [[ PDF]]
~-X.S. Zhang, R.S. Wang, L.Y. Wu, W. Zhang---**Minimum conflict individual haplotyping from SNP fragments and related genotype**---//Evolutionary Bioinformatics//, 2, 271-280, 2006 [[ PDF]]
~-X.S. Zhang, R.S. Wang, L.Y. Wu, L. Chen---**Models and algorithms for the haplotyping problem**---//Current Bioinformatics//, 1(1), 105-114, 2006 [[ PDF]]
~-R.S. Wang, L.M. Wang, M.H. Ha---**Choquet integrals on L-fuzzy sets**---//The Journal of Fuzzy Mathematics//, 14(1), 151-164, 2006 [[ PDF]]
~-R.S. Wang, L.Y. Wu, X.S. Zhang, L. Chen---** A Markov chain model for haplotype assembly from SNP fragments**---//Genome Informatics//, 17(2), 162-171, 2006 [[ PDF]]
~-R.S. Wang, L.Y. Wu, Z. Li, X.S. Zhang---**Haplotype reconstruction from SNP fragments by minimum error correction**---//Bioinformatics//, 21(10), pp: 2456-2462, 2005 [[ PDF]]


~-L. Chen, R.S. Wang, X.S. Zhang---**Biomolecular Networks: Methods and Applications in Systems Biology**---John Wiley & Sons, Hoboken, NJ, 2009 [[ LINK]]

===Research Grants===

~-Several Fundamental Problems in Complex Networks (2007.1-2007.12)
~~& Research Foundation of Renmin University of China, Grant No. 06XNB054, Principal Investigator
~-Research on theory and algorithms of community detection in complex networks (2008.1-2010.12)
~~& National Natural Science Foundation of China (NSFC), Grant No. 10701080, Principal Investigator


~- All models are wrong, but some are useful --- George E.P. Box
~- Everything should be made as simple as possible, but not simpler --- Albert Einstein
~- Nothing in biology makes sense except in the light of evolution --- T. Dobzhansky.
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