""<img src="images/users/wangrs.jpg" alt="Rui-Sheng Wang" style="float: left; margin: 1.0%; padding: 0.5%;">""

====== Dr. Rui-Sheng Wang ======

====== 王瑞省 博士======

[[http://www.phys.psu.edu/ Department of Physics, Pennsylvania State University]]
''Address:'' 104 Davey Lab., University Park, PA 16802, USA
''Tel:'' 1-814-865-4972
''Email:'' rwang@phys.psu.edu

::c::----

=== Research/Professional positions ===

~-08/2008 - present, Postdoctoral Research Fellow in Department of Physics, [[http://www.psu.edu/ Pennsylvania State University]], PA, USA
~-08/2005 - 07/2008 Assistant Professor in School of Information, [[http://www.ruc.edu.cn/ Renmin University of China]], Beijing, China
~~& 10/2006 - 03/2008 Visiting Intelligent Information Lab, [[http://www.osaka-sandai.ac.jp Osaka Sangyo University]], Osaka, Japan.

===Educational Background===

~- 09/2002 - 07/2005, Ph.D. in Operation Research and Control theory, [[http://www.amss.ac.cn Academy of Mathematics & Systems Science, CAS.]]
~- 09/1999 - 07/2002, M.S. in Applied Mathematics, [[http://mc.hbu.cn/ College of Mathematics & Computer Sciences, Hebei University.]]
~- 09/1995 - 07/1999, B.S. in Applied Mathematics, Department of Mathematics, [[http://www.hbu.edu.cn Hebei University.]]

===Research Interests===

~-Systems biology/Computational biology
~~&Biological network inference, analysis, and modeling
~~&Therapeutic target discovery in disease networks
~~&Highthroughput transcriptome/metabolome analysis
~~&Tag SNP/Haplotype inference and disease association
~-Complex networks
~~&Structure and dynamics of complex networks
~-Graph/Optimization theory and application

===Publications===

~[[http://www.ncbi.nlm.nih.gov/pubmed?term=(Wang%20RS%20and%20(Albert%20R%20or%20Zhang%20XS))%20or%20(Wang%2C%20Rui-Sheng%20and%20Chen%20L)%20or%20(Wang%2C%20Ruisheng%20and%20Feng%20E) PubMed]] | [[http://www.informatik.uni-trier.de/~ley/db/indices/a-tree/w/Wang:Rui=Sheng.html DBLP]] | [[http://www.ams.org/mathscinet/search/publications.html?pg4=AUCN&s4=Wang%2C+Rui-Sheng&co4=AND&pg5=TI&s5=&co5=AND&pg6=PC&s6=&co6=AND&pg7=ALLF&s7=&co7=AND&Submit=Search&dr=all&yrop=eq&arg3=&yearRangeFirst=&yearRangeSecond=&pg8=ET&s8=All&review_format=html MathSciNet]]

~-A. Saadatpour, R.S. Wang, A. Liao, X. Liu, T.P. Loughran, I. Albert, R. Albert. **Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia**. //PLoS Computational Biology//, 7(11): e1002267, 2011 [[http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002267 PDF]]
~- R.S. Wang, R. Albert. **Elementary signaling modes predict the essentiality of signal transduction network components**. //BMC Systems Biology//, 5:44, 2011[[http://www.biomedcentral.com/1752-0509/5/44 PDF]]
~-R.S. Wang, S. Pandey, S. Li, T. Gookin, Z. Zhao, R. Albert, S.M. Assmann. **Common and unique elements of the ABA-regulated transcriptome of Arabidopsis guard cells**. //BMC Genomics//, 12:216, 2011 [[http://www.biomedcentral.com/1471-2164/12/216 PDF]]
~-S. Pandey*, R.S. Wang*, L. Wilson, S. Li, Z. Zhao, T. Gookin, S.M. Assmann, R. Albert. **Boolean modeling of transcriptome data reveals novel modes of heterotrimeric G protein action**. //Molecular Systems Biology//, 6:372, 2010 [[http://www.nature.com/msb/journal/v6/n1/full/msb201028.html PDF]] (* Joint first authors)
~-R. Albert, R.S. Wang. **Discrete dynamic modeling of cellular signaling networks**. //Methods in Enzymology//, 467, 281-306, 2009 [[http://www.ncbi.nlm.nih.gov/pubmed/19897097 PDF]]
~-R.S. Wang, G. Jin, X.S. Zhang, L. Chen. **Modeling post-transcriptional regulation activity of small non-coding RNAs in Escherichia coli**. //BMC Bioinformatics//, 10(suppl4):S6, 2009 [[http://www.biomedcentral.com/1471-2105/10/S4/S6 PDF]]
~-Z. Li, R.S. Wang, X.S. Zhang, L. Chen. **Detecting drug targets with minimum side effects in metabolic networks**. //IET Systems Biology//, 3(6), 523-533, 2009 [[http://www.ncbi.nlm.nih.gov/pubmed/19947778 PDF]]
~-X.S. Zhang, R.S. Wang, Y. Wang, J. Wang, Q. Qiu, L. Wang, L. Chen. **Modularity optimization in community detection of complex networks**. //Europhysics Letters//, 87, 38002, 2009 [[http://www.iop.org/EJ/abstract/0295-5075/87/3/38002 PDF]]
~-X.M. Zhao, R.S. Wang, L. Chen, K. Aihara. **Automatic modeling of signaling pathways by network flow model**. //Journal of Bioinformatics and Computational Biology//, 7(2),309-322, 2009 [[http://www.ncbi.nlm.nih.gov/pubmed/19340917 PDF]]
~-Y. Wang, W. Wan, R.S. Wang, E. Feng. **Model, properties and imputation method of missing SNP genotype data utilizing mutual information**. //Journal of Computational and Applied Mathematics//, 229, 168-174, 2009 [[http://dx.doi.org/10.1016/j.cam.2008.10.020 PDF]]
~-L.Y. Wu, Z. Li, R.S. Wang, X.S. Zhang, L. Chen. **Self-organizing map approaches for the haplotype assembly problem**. //Mathematics and Computers in Simulation//, 79(10), 3026-3037, 2009 [[http://dx.doi.org/10.1016/j.matcom.2009.01.021 PDF]]
~- R.S. Wang, S. Zhang, Y. Wang, X.S. Zhang, L. Chen. **Clustering complex networks and biological networks by Nonnegative Matrix Factorization with various similarity measures**. //Neurocomputing,// 72, 134-141, 2008. [[http://dx.doi.org/10.1016/j.neucom.2007.12.043 PDF]]
~- R.S. Wang, M.H. Ha. **On the properties of sequences of fuzzy-valued Choquet integrable function**. //Fuzzy Optimization and Decision Making//, 7(4), 417-431, 2008 [[http://www.springerlink.com/content/3135381p7880t717/ PDF]]
~-X.M. Zhao, R.S. Wang, L. Chen, K. Aihara. **Uncovering signal transduction networks from high-throughput data by integer linear programming**. //Nucleic Acids Research//, 36, e48, 2008 [[http://nar.oxfordjournals.org/cgi/content/abstract/36/9/e48 PDF]]
~-Z. Li, S. Zhang, R.S. Wang, X.S. Zhang and L. Chen. **Quantitative function for community detection**. //Physical Review E//, 77, 036109, 2008 [[http://pre.aps.org/abstract/PRE/v77/i3/e036109 PDF]]
~-R.S. Wang, Y. Wang, X.S. Zhang, L. Chen. **Detecting community structure in complex networks by optimal rearrangement clustering**. //Lecture Notes in Artificial Intelligence// (PAKDD 2007 workshop), 4819,119-130, 2007 [[http://www.springerlink.com/content/p815210h2x030wq0/ PDF]]
~-R.S. Wang, Y. Wang, L.Y. Wu, X.S. Zhang, L. Chen. **Analysis on multi-domain cooperation for predicting protein-protein interactions**. //BMC Bioinformatics//, 8:391, 2007 [[http://www.biomedcentral.com/1471-2105/8/391/abstract PDF]]
~-R.S. Wang, X.S. Zhang, L. Chen. **Inferring transcriptional interactions and regulator activities from experimental data**. //Molecules and Cells//, 24(3), 307-315, 2007 [[http://www.ncbi.nlm.nih.gov/pubmed/18182844 PDF]]
~-R.S. Wang, Y. Wang, X.S. Zhang, L. Chen. **Inferring transcriptional regulatory networks from high-throughput data**. //Bioinformatics//, 23, 3056-3064, 2007 [[http://bioinformatics.oxfordjournals.org/cgi/content/abstract/btm465v1 PDF]]
~-R.S. Wang, S. Zhang, X.S. Zhang, L. Chen. **Identifying modules in complex networks by a graph-theoretical method and its application in protein interaction networks**. //Lecture Notes in Artificial Intelligence// (ICIC2007), 4682, 1090-1101, 2007 [[http://www.springerlink.com/content/gp6861366h541474/ PDF]]
~-S. Zhang, R.S. Wang, X.S. Zhang. **Uncovering fuzzy community structure in complex networks**. //Physical Review E//, 76, 046103, 2007 [[http://link.aps.org/abstract/PRE/v76/e046103 PDF]]
~-S. Zhang, R.S. Wang, X.S. Zhang. **Identification of overlapping community structure in complex networks using fuzzy c-means clustering**. //Physica A//, 374, 483–490, 2007 [[http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TVG-4KKFYKY-3&_user=5361375&_coverDate=01%2F15%2F2007&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000066948&_version=1&_urlVersion=0&_userid=5361375&md5=d293363358012e4536deb99ca67bbd3a PDF]]
~-Y. Wang, E. Feng, R.S. Wang, D. Zhang. **Haplotype assembly model with genotype information and local exhaustive search algorithm**. //Computational Biology and Chemistry//, 31(4): 288-293, 2007 [[http://www.ncbi.nlm.nih.gov/pubmed/17631422 PDF]]
~-X.S. Zhang, R.S. Wang, L.Y. Wu, W. Zhang. **Minimum conflict individual haplotyping from SNP fragments and related genotype**. //Evolutionary Bioinformatics//, 2, 271-280, 2006 [[http://www.la-press.com/minimum-conflict-individual-haplotyping-from-snp-fragments-and-related-a133 PDF]]
~-X.S. Zhang, R.S. Wang, L.Y. Wu, L. Chen. **Models and algorithms for the haplotyping problem**. //Current Bioinformatics//, 1(1), 105-114, 2006 [[http://www.bentham.org/cbio/Samples/cbio1-1/Chen.pdf PDF]]
~-R.S. Wang, L.M. Wang, M.H. Ha. **Choquet integrals on L-fuzzy sets**. //The Journal of Fuzzy Mathematics//, 14(1), 151-164, 2006 [[http://direct.bl.uk/bld/PlaceOrder.do?UIN=185847315&ETOC=RN&from=searchengine PDF]]
~-R.S. Wang, M.H. Ha. **On Choquet integrals of fuzzy-valued functions**. //The Journal of Fuzzy Mathematics//, 14(1), 89-102, 2006 [[http://direct.bl.uk/bld/OrderDetails.do?did=1&uin=185847273 PDF]]
~-R.S. Wang, L.Y. Wu, X.S. Zhang, L. Chen.** A Markov chain model for haplotype assembly from SNP fragments**. //Genome Informatics//, 17(2), 162-171, 2006 [[http://www.ncbi.nlm.nih.gov/pubmed/17503389 PDF]]
~-R.S. Wang, L.Y. Wu, Z. Li, X.S. Zhang. **Haplotype reconstruction from SNP fragments by minimum error correction**. //Bioinformatics//, 21(10), pp: 2456-2462, 2005 [[http://bioinformatics.oupjournals.org/cgi/content/abstract/21/10/2456 PDF]]
~-R.S. Wang, X.S. Zhang, L. Sheng. **Haplotype inference by pure parsimony via genetic algorithm**. //Lecture Notes in Operations Research// (ISORA2005), 5, 308-318, 2005 [[http://www.aporc.org/LNOR/5/ISORA2005F25.pdf PDF]]

===Books===

~-L. Chen, R.S. Wang, X.S. Zhang. **[[http://www.wiley.com/WileyCDA/WileyTitle/productCd-0470243732.html Biomolecular Networks: Methods and Applications in Systems Biology]]**. John Wiley & Sons, Hoboken, NJ, 2009

===Research Grants===

~-Several Fundamental Problems in Complex Networks (2007.1-2007.12)
~~& Research Foundation of Renmin University of China, Grant No. 06XNB054, Principal Investigator
~-Research on theory and algorithms of community detection in complex networks (2008.1-2010.12)
~~& National Natural Science Foundation of China (NSFC), Grant No. 10701080, Principal Investigator

===Quotations===

~- All models are wrong, but some are useful --- George E.P. Box
~- Everything should be made as simple as possible, but not simpler --- Albert Einstein
~- Nothing in biology makes sense except in the light of evolution --- T. Dobzhansky.