Dr. Rui-Sheng Wang
王瑞省 博士
Department of Physics, Pennsylvania State University
Address: 104 Davey Lab., University Park, PA 16802, USA
Tel: 1-814-865-4972
Email: rwang@phys.psu.edu
Research/Professional positions
- 08/2008 - present, Postdoctoral Research Fellow in Department of Physics, Pennsylvania State University, PA, USA
- 08/2005 - 07/2008 Assistant Professor in School of Information, Renmin University of China, Beijing, China
- 10/2006 - 03/2008 Visiting Intelligent Information Lab, Osaka Sangyo University, Osaka, Japan.
Educational Background
- 09/2002 - 07/2005, Ph.D. in Operation Research and Control theory, Academy of Mathematics & Systems Science, CAS.
- 09/1999 - 07/2002, M.S. in Applied Mathematics, College of Mathematics & Computer Sciences, Hebei University.
- 09/1995 - 07/1999, B.S. in Applied Mathematics, Department of Mathematics, Hebei University.
Research Interests
- Systems biology/Computational biology
- Biological network inference, analysis, and modeling
- Therapeutic target discovery in disease networks
- Highthroughput transcriptome/metabolome analysis
- Tag SNP/Haplotype inference and disease association
- Complex networks
- Structure and dynamics of complex networks
- Graph/Optimization theory and application
Publications
- A. Saadatpour, R.S. Wang, A. Liao, X. Liu, T.P. Loughran, I. Albert, R. Albert. Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia. PLoS Computational Biology, 7(11): e1002267, 2011 PDF
- R.S. Wang, R. Albert. Elementary signaling modes predict the essentiality of signal transduction network components. BMC Systems Biology, 5:44, 2011PDF
- R.S. Wang, S. Pandey, S. Li, T. Gookin, Z. Zhao, R. Albert, S.M. Assmann. Common and unique elements of the ABA-regulated transcriptome of Arabidopsis guard cells. BMC Genomics, 12:216, 2011 PDF
- S. Pandey*, R.S. Wang*, L. Wilson, S. Li, Z. Zhao, T. Gookin, S.M. Assmann, R. Albert. Boolean modeling of transcriptome data reveals novel modes of heterotrimeric G protein action. Molecular Systems Biology, 6:372, 2010 PDF (* Joint first authors)
- R. Albert, R.S. Wang. Discrete dynamic modeling of cellular signaling networks. Methods in Enzymology, 467, 281-306, 2009 PDF
- R.S. Wang, G. Jin, X.S. Zhang, L. Chen. Modeling post-transcriptional regulation activity of small non-coding RNAs in Escherichia coli. BMC Bioinformatics, 10(suppl4):S6, 2009 PDF
- Z. Li, R.S. Wang, X.S. Zhang, L. Chen. Detecting drug targets with minimum side effects in metabolic networks. IET Systems Biology, 3(6), 523-533, 2009 PDF
- X.S. Zhang, R.S. Wang, Y. Wang, J. Wang, Q. Qiu, L. Wang, L. Chen. Modularity optimization in community detection of complex networks. Europhysics Letters, 87, 38002, 2009 PDF
- X.M. Zhao, R.S. Wang, L. Chen, K. Aihara. Automatic modeling of signaling pathways by network flow model. Journal of Bioinformatics and Computational Biology, 7(2),309-322, 2009 PDF
- Y. Wang, W. Wan, R.S. Wang, E. Feng. Model, properties and imputation method of missing SNP genotype data utilizing mutual information. Journal of Computational and Applied Mathematics, 229, 168-174, 2009 PDF
- L.Y. Wu, Z. Li, R.S. Wang, X.S. Zhang, L. Chen. Self-organizing map approaches for the haplotype assembly problem. Mathematics and Computers in Simulation, 79(10), 3026-3037, 2009 PDF
- R.S. Wang, S. Zhang, Y. Wang, X.S. Zhang, L. Chen. Clustering complex networks and biological networks by Nonnegative Matrix Factorization with various similarity measures. Neurocomputing, 72, 134-141, 2008. PDF
- R.S. Wang, M.H. Ha. On the properties of sequences of fuzzy-valued Choquet integrable function. Fuzzy Optimization and Decision Making, 7(4), 417-431, 2008 PDF
- X.M. Zhao, R.S. Wang, L. Chen, K. Aihara. Uncovering signal transduction networks from high-throughput data by integer linear programming. Nucleic Acids Research, 36, e48, 2008 PDF
- Z. Li, S. Zhang, R.S. Wang, X.S. Zhang and L. Chen. Quantitative function for community detection. Physical Review E, 77, 036109, 2008 PDF
- R.S. Wang, Y. Wang, X.S. Zhang, L. Chen. Detecting community structure in complex networks by optimal rearrangement clustering. Lecture Notes in Artificial Intelligence (PAKDD 2007 workshop), 4819,119-130, 2007 PDF
- R.S. Wang, Y. Wang, L.Y. Wu, X.S. Zhang, L. Chen. Analysis on multi-domain cooperation for predicting protein-protein interactions. BMC Bioinformatics, 8:391, 2007 PDF
- R.S. Wang, X.S. Zhang, L. Chen. Inferring transcriptional interactions and regulator activities from experimental data. Molecules and Cells, 24(3), 307-315, 2007 PDF
- R.S. Wang, Y. Wang, X.S. Zhang, L. Chen. Inferring transcriptional regulatory networks from high-throughput data. Bioinformatics, 23, 3056-3064, 2007 PDF
- R.S. Wang, S. Zhang, X.S. Zhang, L. Chen. Identifying modules in complex networks by a graph-theoretical method and its application in protein interaction networks. Lecture Notes in Artificial Intelligence (ICIC2007), 4682, 1090-1101, 2007 PDF
- S. Zhang, R.S. Wang, X.S. Zhang. Uncovering fuzzy community structure in complex networks. Physical Review E, 76, 046103, 2007 PDF
- S. Zhang, R.S. Wang, X.S. Zhang. Identification of overlapping community structure in complex networks using fuzzy c-means clustering. Physica A, 374, 483–490, 2007 PDF
- Y. Wang, E. Feng, R.S. Wang, D. Zhang. Haplotype assembly model with genotype information and local exhaustive search algorithm. Computational Biology and Chemistry, 31(4): 288-293, 2007 PDF
- X.S. Zhang, R.S. Wang, L.Y. Wu, W. Zhang. Minimum conflict individual haplotyping from SNP fragments and related genotype. Evolutionary Bioinformatics, 2, 271-280, 2006 PDF
- X.S. Zhang, R.S. Wang, L.Y. Wu, L. Chen. Models and algorithms for the haplotyping problem. Current Bioinformatics, 1(1), 105-114, 2006 PDF
- R.S. Wang, L.M. Wang, M.H. Ha. Choquet integrals on L-fuzzy sets. The Journal of Fuzzy Mathematics, 14(1), 151-164, 2006 PDF
- R.S. Wang, M.H. Ha. On Choquet integrals of fuzzy-valued functions. The Journal of Fuzzy Mathematics, 14(1), 89-102, 2006 PDF
- R.S. Wang, L.Y. Wu, X.S. Zhang, L. Chen. A Markov chain model for haplotype assembly from SNP fragments. Genome Informatics, 17(2), 162-171, 2006 PDF
- R.S. Wang, L.Y. Wu, Z. Li, X.S. Zhang. Haplotype reconstruction from SNP fragments by minimum error correction. Bioinformatics, 21(10), pp: 2456-2462, 2005 PDF
- R.S. Wang, X.S. Zhang, L. Sheng. Haplotype inference by pure parsimony via genetic algorithm. Lecture Notes in Operations Research (ISORA2005), 5, 308-318, 2005 PDF
Books
- L. Chen, R.S. Wang, X.S. Zhang. Biomolecular Networks: Methods and Applications in Systems Biology. John Wiley & Sons, Hoboken, NJ, 2009
Research Grants
- Several Fundamental Problems in Complex Networks (2007.1-2007.12)
- Research Foundation of Renmin University of China, Grant No. 06XNB054, Principal Investigator
- Research on theory and algorithms of community detection in complex networks (2008.1-2010.12)
- National Natural Science Foundation of China (NSFC), Grant No. 10701080, Principal Investigator
Quotations
- All models are wrong, but some are useful
George E.P. Box - Everything should be made as simple as possible, but not simpler
Albert Einstein - Nothing in biology makes sense except in the light of evolution
T. Dobzhansky.
