Dr. Rui-Sheng Wang

王瑞省 博士

Department of Physics, Pennsylvania State University
Address: 121 Davey Lab., University Park, PA 16802, USA
Tel: 1-814-865-4972
Email: rwang@phys.psu.edu

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Research/Professional positions

• 08/2008 - present, Postdoctoral Research Fellow in Department of Physics, Pennsylvania State University, PA, USA
• 08/2005 - 07/2008 Assistant Professor in School of Information, Renmin University of China, Beijing, China
  • 10/2006 - 03/2008 Visiting Intelligent Information Lab, Osaka Sangyo University, Osaka, Japan.

Educational Background

• 09/2002 - 07/2005, Ph.D. in Operation Research and Control theory, Academy of Mathematics & Systems Science, CAS.
• 09/1999 - 07/2002, M.S. in Applied Mathematics, College of Mathematics & Computer Sciences, Hebei University.
• 09/1995 - 07/1999, B.S. in Applied Mathematics, Department of Mathematics, Hebei University.

Research Interests

• Systems biology/Bioinformatics
  • Biological network inference, modeling and analysis
  • Microarray gene expression data analysis
  • Tag SNP/Haplotype inference and reconstruction
• Complex networks
  • Structure and dynamics of complex networks
• Graph/Optimization theory and application

Publications

1. S. Pandey*, R.S. Wang*, L. Wilson, S. Li, Z. Zhao, T. Gookin, S.M. Assmann, R. Albert. Boolean modeling of transcriptome data reveals novel modes of heterotrimeric G protein action. Molecular Systems Biology, 6:372, 2010 PDF (* Joint first authors)
2. R. Albert, R.S. Wang. Discrete dynamic modeling of cellular signaling networks. Methods in Enzymology, 467, 281-306, 2009 PDF
3. R.S. Wang, G. Jin, X.S. Zhang, L. Chen. Modeling post-transcriptional regulation activity of small non-coding RNAs in Escherichia coli. BMC Bioinformatics, 10(suppl4):S6, 2009 PDF
4. Z. Li, R.S. Wang, X.S. Zhang, L. Chen. Detecting drug targets with minimum side effects in metabolic networks. IET Systems Biology, 3(6), 523-533, 2009 PDF
5. X.S. Zhang, R.S. Wang, Y. Wang, J. Wang, Q. Qiu, L. Wang, L. Chen. Modularity optimization in community detection of complex networks. Europhysics Letters, 87, 38002, 2009 PDF
6. X.M. Zhao, R.S. Wang, L. Chen, K. Aihara. Automatic modeling of signaling pathways by network flow model. Journal of Bioinformatics and Computational Biology, 7(2),309-322, 2009 PDF
7. Y. Wang, W. Wan, R.S. Wang, E. Feng. Model, properties and imputation method of missing SNP genotype data utilizing mutual information. Journal of Computational and Applied Mathematics, 229, 168-174, 2009 PDF
8. L.Y. Wu, Z. Li, R.S. Wang, X.S. Zhang, L. Chen. Self-organizing map approaches for the haplotype assembly problem. Mathematics and Computers in Simulation, 79(10), 3026-3037, 2009 PDF
9. R.S. Wang, S. Zhang, Y. Wang, X.S. Zhang, L. Chen. Clustering complex networks and biological networks by Nonnegative Matrix Factorization with various similarity measures. Neurocomputing, 72, 134-141, 2008. PDF
10. R.S. Wang, M.H. Ha. On the properties of sequences of fuzzy-valued Choquet integrable function. Fuzzy Optimization and Decision Making, 7(4), 417-431, 2008 PDF
11. X.M. Zhao, R.S. Wang, L. Chen, K. Aihara. Uncovering signal transduction networks from high-throughput data by integer linear programming. Nucleic Acids Research, 36, e48, 2008 PDF
12. J. Wang, Y. Qiu, R.S. Wang, X.S. Zhang. Remarks on network community properties. Journal of System Science and Complexity, 21(4), 629-636, 2008 PDF
13. Z. Li, S. Zhang, R.S. Wang, X.S. Zhang and L. Chen. Quantitative function for community detection. Physical Review E, 77, 036109, 2008 PDF
14. R.S. Wang, Y. Wang, X.S. Zhang, L. Chen. Detecting community structure in complex networks by optimal rearrangement clustering. Lecture Notes in Artificial Intelligence (PAKDD 2007 workshop), 4819,119-130, 2007 PDF
15. R.S. Wang, Y. Wang, L.Y. Wu, X.S. Zhang, L. Chen. Analysis on multi-domain cooperation for predicting protein-protein interactions. BMC Bioinformatics, 8:391, 2007 PDF
16. R.S. Wang, X.S. Zhang, L. Chen. Inferring transcriptional interactions and regulator activities from experimental data. Molecules and Cells, 24(3), 307-315, 2007 PDF
17. R.S. Wang, Y. Wang, X.S. Zhang, L. Chen. Inferring transcriptional regulatory networks from high-throughput data. Bioinformatics, 23, 3056-3064, 2007 PDF
18. R.S. Wang, S. Zhang, X.S. Zhang, L. Chen. Identifying modules in complex networks by a graph-theoretical method and its application in protein interaction networks. Lecture Notes in Artificial Intelligence (ICIC2007), 4682, 1090-1101, 2007 PDF
19. S. Zhang, R.S. Wang, X.S. Zhang. Uncovering fuzzy community structure in complex networks. Physical Review E, 76, 046103, 2007 PDF
20. S. Zhang, R.S. Wang, X.S. Zhang. Identification of overlapping community structure in complex networks using fuzzy c-means clustering. Physica A, 374, 483–490, 2007 PDF
21. Y. Wang, E. Feng, R.S. Wang, D. Zhang. Haplotype assembly model with genotype information and local exhaustive search algorithm. Computational Biology and Chemistry, 31(4): 288-293, 2007 PDF
22. X.S. Zhang, R.S. Wang, L.Y. Wu, W. Zhang. Minimum conflict individual haplotyping from SNP fragments and related genotype. Evolutionary Bioinformatics, 2, 271-280, 2006 PDF
23. X.S. Zhang, R.S. Wang, L.Y. Wu, L. Chen. Models and algorithms for the haplotyping problem. Current Bioinformatics, 1(1), 105-114, 2006 PDF
24. R.S. Wang, L.Y. Wu, X.S. Zhang, L. Chen. A Markov chain model for haplotype assembly by SNP fragments. Genome Informatics, 17(2), 162-171, 2006 PDF
25. R.S. Wang, L.Y. Wu, Z. Li, X.S. Zhang. Haplotype reconstruction from SNP fragments by minimum error correction. Bioinformatics, 21(10), pp: 2456-2462, 2005 PDF
26. R.S. Wang, X.S. Zhang, L. Sheng. Haplotype inference by pure parsimony via genetic algorithm. Lecture Notes in Operations Research (ISORA2005), 5, 308-318, 2005 PDF
27. Y.Y. Zhao, L.Y. Wu, J.H. Zhang, R.S. Wang, X.S. Zhang. Haplotype assembly from weighted SNP fragments. Computational Biology and Chemistry, 29(4), 281-287, 2005 PDF
28. R.S. Wang, L.M. Wang, M.H. Ha. Choquet integrals on L-fuzzy sets. The Journal of Fuzzy Mathematics, 14(1), 151-164, 2006 PDF
29. R.S. Wang, M.H. Ha. On Choquet integrals of fuzzy-valued functions. The Journal of Fuzzy Mathematics, 14(1), 89-102, 2006 PDF
30. M.H. Ha, R.S. Wang, C.X. Wu. Outer measures and inner measures on fuzzy measure space. The Journal of Fuzzy Mathematics, (10)1, 127-132, 2002

Books

• L. Chen, R.S. Wang, X.S. Zhang. Biomolecular Networks: Methods and Applications in Systems Biology. John Wiley & Sons, Hoboken, NJ, 2009

Research Grants

• Several Fundamental Problems in Complex Networks (2007)
  • Research Foundation of Renmin University of China, Grant No. 06XNB054, Principal Investigator
• Research on theory and algorithms of community detection in complex networks (2008-2010)
  • National Natural Science Foundation of China (NSFC), Grant No. 10701080, Principal Investigator

Quotations

• All models are wrong, but some are useful
  George E.P. Box
• Nothing in biology makes sense except in the light of evolution
  T. Dobzhansky