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====== Prof. Jiguang Wang ======

""<img src="images/users/wjg3.JPG" alt="Jiguang Wang in Chengdu" style="float: right; margin: 0.0%; padding: 0.0%;">""

[[ Assistant Professor]] | [[ Lab Page at HKUST]] | [[ 中文网页]] | Email:

Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong

Jiguang Wang was born in Cangxian Hebei, China. He got his Ph.D. degree from AMSS of CAS in July 2011, and now is working at Hong Kong University of Sciecne and Technology as an Assistant Professor.

** {{image alt="New!" title="New!" url="images/new.gif"}} ** [[ Opening positions in Hong Kong University of Science and Technology.]]

=== {{color c="green" text=" Experience"}} ===
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~- **2016-now** Assistant Professor, Hong Kong University of Science and Technology
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~- **2015-2016** Associate Research Scientist, Columbia University
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~- **2011-2011** Visiting Scholar, University of Missouri
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~- **2011-2013** Research Assistant Professor, Beijing Institute of Genomics

=== {{color c="green" text=" Training and Education"}} ===
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~- **2011-2015** Postdoctoral Research Scientist, Columbia University
{{image class="left" alt="AMSS logo" url="images/users/wjg9.png" link=""}}
~- **2006-2011** PhD in Applied Mathematics, AMSS, CAS
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~- **2006-2011** Visiting Students, Shanghai Institute for Biological Sciences
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~- **2002-2006** ScB in Applied Mathematics, Beijing Institute of Technology

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=== {{color c="green" text="Research Interests"}} ===
~- Precision Medicine
~- Cancer Genomics and Next Generation Sequencing
~- Transcriptome Assembly and Non-coding RNAs
~- Network Biology and Systems Biology
~- Operations Reseach
~- Machine Learning

=== {{color c="green" text="Research Projects"}} ===
~- **2015-** Topology of Cancer Evolution and Heterogeneity, Co-Investigator, NCI-U54
~- **2014-2018** Provocative Questions: Reconstruction of Evolutionary Networks using Cross-Sectional Genomic Data, Co-Investigator, NCI-R01
~- **2009-2010** The research of dynamic model and algorithms for network biomarkers in type 2 diabetes, Principal Investigator, Ph. D research project supported by Chinese Academy of Sciences

=== {{color c="green" text="Awards and Honors"}} ===
~- **2016** [[ Travel Fellowship of SYSTEMS APPROACHES TO CANCER BIOLOGY (SACB meeting)]]
~- **2015** [[ Precision Medicine Fellowship, Irving Institute for Clinical and Translational Research]]
~- **2014** Travel Fellowship of 10th International Symposium on Bioinformatics Research and Applications
~- **2012** [[ Excellent PhD thesis Award of Chinese Academy of Science]]
~- **2011** [[ Special Prize of President Scholarship for Postgraduate Students of Chinese Academy of Science]]
~- **2009** [[ The Presidential Outstanding Research Scholarship from AMSS, CAS]]
~- **2007** Merit Student in AMSS
~- **2006** Beijing Outstanding Graduates and Admission with waiver of postgraduate entrance examination
~- **2005** Honorable Prize in Mathematical Contest in Modeling and Second class Prize in CUMCM
~- **2004** Second class Prize in CUMCM
~- **2002** First class Prize in Chinese Mathematical Olympiad and Admission with waiver of national college admission examination

=== {{color c="green" text="Selected Publications"}} ===
[[ Google Citation]] | [[ ResearcherID:B-2717-2012]] | [[ ResearchGate]]

{{image class="left" alt="srep logo" url="images/users/wjg_NG2016.png" link=""}}
~~ Clonal Evolution of Glioblastoma under Therapy.
~~ **[[ Jiguang Wang]]**, Emanuela Cazzato, Erik Ladewig, Veronique Frattini, Daniel I. S. Rosenbloom, Sakellarios Zairis, Francesco Abate, Zhaoqi Liu, Oliver Elliott, Yong-Jae Shin, Jin-Ku Lee, In-Hee Lee, Woong-Yang Park, Marica Eoli, Andrew Blumberg, Anna Lasorella, Do-Hyun Nam#, Gaetano Finocchiaro#, Antonio Iavarone#, Raul Rabadan#.
~~ //Nature Genetics//, 48, 768–776, 2016. --- ** {{image alt="New!" title="New!" url="images/new.gif"}} **

{{image class="left" alt="srep logo" url="images/users/wjg28_elife.png" link=""}}
~~ [[ Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topoisomerase I inhibitors.]]
~~ Kenta Yamamoto, **[[ Jiguang Wang]]**, Lisa Sprinzen, Jun Xu, Christopher J. Haddock, Chen Li, Brian J. Lee, Denis G. Loredan, Wenxia Jiang, Alessandro Vindigni, Dong Wang, Raul Rabadan and Shan Zha.
~~//eLife//, 10.7554/eLife.14709, 2016.

{{image class="left" alt="srep logo" url="images/users/wjg_cell.png" link=""}}
~~ RNA-Exosome-Regulated Long Non-coding RNA Transcription Controls Super-Enhancer Activity.
~~ Evangelos Pefanis*, **[[ Jiguang Wang*]]**, Gerson Rothschild*, Junghyun Lim*, Kazadi D, Sun J, Federation A, Chao J, Elliott O, Liu ZP, Economides AN, Bradner JE, Rabadan R, Basu U.
~~ //Cell//, Volume 161, Issue 4, p774–789, 7 May 2015. (*First authors) [[ EXOTOME browser]]

{{image class="left" alt="srep logo" url="images/users/wjg28_elife.png" link=""}}
~~ [[ Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia]]
~~ **[[ Jiguang Wang#]]**, Hossein Khiabanian, Davide Rossi, Giulia Fabbri, Valter Gattei, Francesco Forconi, Luca Laurenti, Roberto Marasca, Giovanni Del Poeta, Robin Foà, Laura Pasqualucci, Gianluca Gaidano, Raul Rabadan#.
~~//eLife//, DOI:10.7554/eLife.02869, 2014. (#corresponding authors). [[ :::News in Columbia:::]] ---

{{image class="left" alt="srep logo" url="images/users/wjg27.png" link=""}}
~~ [[ Noncoding RNA transcription targets AID to divergently transcribed loci in B cells]]
~~ Evangelos Pefanis*, **[[ Jiguang Wang*]]**, Gerson Rothschild*, Junghyun Lim, Jaime Chao, Raul Rabadan, Aris N. Economides, Uttiya Basu
~~ //Nature//, 514(7522), 389–393, doi:10.1038/nature13580, 2014. (* co-first authors). --- [[ :::This paper has been evaluated by F1000:::]]

{{image class="left" alt="srep logo" url="images/users/wjg_cell2016.png" link=""}}
~~ Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
~~ Michele Ceccarelli, Floris P Barthel, Tathiane M Malta, Thais S Sabedot, Sofie R Salama, Bradley A Murray, Olena Morozova, Yulia Newton, Amie Radenbaugh, Stefano M Pagnotta, Samreen Anjum, **[[ Jiguang Wang]]**, Ganiraju Manyam, Pietro Zoppoli, Shiyun Ling, Arjun A Rao, Mia Grifford, Andrew D Cherniack, Hailei Zhang, Laila Poisson, Carlos Gilberto Carlotti, Daniela Pretti da Cunha Tirapelli, Arvind Rao, Tom Mikkelsen, Ching C Lau, WK Alfred Yung, Raul Rabadan, Jason Huse, Daniel J Brat, Norman L Lehman, Jill S Barnholtz-Sloan, Siyuan Zheng, Kenneth Hess, Ganesh Rao, Matthew Meyerson, Rameen Beroukhim, Lee Cooper, Rehan Akbani, Margaret Wrensch, David Haussler, Kenneth D Aldape, Peter W Laird, David H Gutmann, TCGA Research Network, Houtan Noushmehr, Antonio Iavarone, Roel GW Verhaak.
~~ //Cell//, Volume 164, Issue 3, 550-563, 2016.

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~~ Transcriptomics identify CD9 as a marker of murine IL10-competent regulatory B cells.
~~ Jianbo Sun, **[[ Jiguang Wang]]**, Evangelos Pefanis, Jaime Chao, Gerson Rothschild, Isao Tachibana, Jun Kui Chen, Ivaylo I. Ivanov, Raul Rabadan, Yoshito Takeda, Uttiya Basu
~~ //Cell Reports//, Volume 13, Issue 6, p1110–1117, 10 November 2015.

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~~ NOA: a novel Network Ontology Analysis method.
~~ **[[ Jiguang Wang]]**, Qiang Huang, Zhi-Ping Liu, Yong Wang, Ling-Yun Wu, Luonan Chen, Xiang-Sun Zhang.
~~ //Nucleic Acids Research//, doi: 10.1093/nar/gkr251, 2011.
~~ [[ ::NOA Webserver::]] [[ :::This paper has been evaluated by F1000:::]]

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~~ Disease-aging network reveals significant roles of aging genes in connecting genetic diseases.
~~ **[[ Jiguang Wang]]**, Shihua Zhang, Yong Wang, Luonan Chen, and Xiang-Sun Zhang.
~~ //PLoS Comput Biol//, 5(9): e1000521. doi:10.1371/journal.pcbi.1000521, 2009.---

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~~ Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes.
~~ M Messina*, S Chiaretti*, **[[ Jiguang Wang*]]**, AL Fedullo, N Peragine, V Gianfelici, A Piciocchi, F Brugnoletti, F Di Giacomo, S Pauselli, AB Holmes, MC Puzzolo, G Ceglie, V Apicella, M Mancini, G Te Kronnie, AM Testi, A Vitale, M Vignetti, A Guarini, R Rabadan, R Foà.
~~ //Oncotarget//, doi: 10.18632/oncotarget.7356, 2016. --- [[ :::This paper has been evaluated by F1000:::]]

{{image class="left" alt="srep logo" url="images/users/wjg_mbs2016.png" link="!divAbstract"}}
~~ Network stratification analysis for identifying function-specific network layers.
~~ C Zhang*, **[[ Jiguang Wang*]]**, C Zhang, J Liu, D Xu, L Chen.
~~ //Molecular BioSystems//, 12(4):1232-40, 2016.

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~~ [[ Inter- and intra-patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidences from circulating and lymph nodal compartments]]
~~ Ilaria Del Giudice*, Marilisa Marinelli*, **[[ Jiguang Wang*]]**, Silvia Bonina, Monica Messina, Sabina Chiaretti, Caterina Ilari, Luciana Cafforio, Sara Raponi, Francesca R. Mauro, Valeria Di Maio, Maria S. De Propris, Mauro Nanni, Carmela Ciardullo, Davide Rossi, Gianluca Gaidano, Anna Guarini, Raul Rabadan and Robin Foà.
~~ //British Journal of Haematology//, DOI: 10.1111/bjh.13859, 2015. (* co-first authors).

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~~ An information theoretic method to identify combinations of genomic alterations that promote glioblastoma.
~~ Rachel D. Melamed, **[[ Jiguang Wang]]**, Antonio Iavarone and Raul Rabadan.
~~ //J Mol Cell Biol//, doi: 10.1093/jmcb/mjv026, 2015.

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~~ Network propagation reveals novel genetic features predicting drug response of cancer cell lines.
~~ **[[ Jiguang Wang*]]**, Judith Kribelbauer*, Raul Rabadan.
~~ //Current Bioinformatics//, Volume 11, issue 5, 2016.

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~~ The research on molecular network models of complex disease (in Chinese)
~~**[[ Jiguang Wang*]]**
~~ //Sci Sin Math//, 44(4): 317-328, doi: 10.1360/012013-143, 2014.

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~~ Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia
~~ D Rossi, H Khiabanian, V Spina, C Ciardullo, A Bruscaggin, R Famà, Silvia Rasi, Sara Monti, Clara Deambrogi, Lorenzo De Paoli, **[[ Jiguang Wang]]**, Valter Gattei, Anna Guarini, Robin Foà, Raul Rabadan, and Gianluca Gaidano
~~ //Blood//, blood-2013-11-539726, 2014.

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~~ PU. 1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway
~~ J Zhou, J Wu, B Li, D Liu, J Yu, X Yan, S Zheng, **[[ J Wang]]**, L Zhang, L Zhang, F He, Q Li, A Chen, Y Zhang, X Zhao, Y Guan, X Zhao, J Yan, J Ni, M A Nobrega, B Löwenberg, R Delwel, P J M Valk, A Kumar, L Xie, D G Tenen, G Huang and Q-f Wang
~~ //Leukemia//, doi: 10.1038/leu.2013.384, 2014.

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~~ Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome.
~~ Giulia Fabbri, Hossein Khiabanian, Antony B Holmes, **[[ Jiguang Wang]]**, Monica Messina, Charles G Mullighan, Laura Pasqualucci, Raul Rabadan, Riccardo Dalla-Favera
~~ //Journal of Experimental Medicine//, 10/2013; DOI:10.1084/jem.20131448, 2013.

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~~ E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells.
~~ Jianbo Sun, Celia D. Keim, **[[ Jiguang Wang]]**, David Kazadi, Paula M. Oliver, Raul Rabadan and Uttiya Basu
~~ //Genes & Dev.//, 27: 1821-1833, 2013.

{{image class="left" alt="srep logo" url="images/users/wjg24.png" link=""}}
~~ B cell development and IL-10 secretion.
~~Uttiya Basu, Jianbo Sun, and **[[ Jiguang Wang]]**
~~//The Journal of Immunology//, 190, 174.23, 2013.

{{image class="left" alt="srep logo" url="images/users/wjg19.gif" link=""}}
~~ NOA: A Cytoscape Plugin for Network Ontology Analysis.
~~ Chao Zhang*, **[[ Jiguang Wang*]]**, Kristina Hanspers, Dong Xu, Luonan Chen, Alexander R. Pico.
~~ //Bioinformatics//, 29 (16): 2066-2067, 2013. (* co-first authors)
~~ [[ NOA is now available in Cytoscape!! App store and Plug-in manager]]

{{image class="left" alt="srep logo" url="images/users/wjg11.png" link=""}}
~~ APG: an Active Protein-Gene Network Model to Quantify Regulatory Signals in Complex Biological Systems.
~~ **[[ Jiguang Wang]]**, Yidan Sun, Si Zheng, Xiang-Sun Zhang, Hua-Rong Zhou, Luonan Chen.
~~ //Scientific Reports//, 3 : 1097, DOI: 10.1038/srep01097, 2013.

{{image class="left" alt="JMCB logo" url="images/users/wjg14.png" link=""}}
~~ Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis.
~~ Wei Song*, **[[ Jiguang Wang*]]**, Ying Yang, Nai-He Jing, Xiang-Sun Zhang, Luonan Chen, Jia-Rui Wu
~~ //Journal of Molecular Cell Biology // 4(3), doi: 10.1093/jmcb/mjs029, 2012 (* co-first authors).

{{image class="left" alt="Cancer Letters logo" url="images/users/wjg12.png" link=""}}
~~ Whole-exome Sequencing Reveals Recurrent Somatic Mutation Networks in Cancer.
~~ Xiaoping Liu*, **[[ Jiguang Wang*]]**, Luonan Chen.
~~ //Cancer Letters//, 2012 (* co-first authors).

{{image class="left" alt="JEM logo" url="images/users/wjg13.png" link=""}}
~~ The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development.
~~ Davide Rossi, Vladimir Trifonov, Marco Fangazio, Alessio Bruscaggin, Silvia Rasi, Valeria Spina, Sara Monti, Tiziana Vaisitti, Francesca Arruga, Rosella Famà, Carmela Ciardullo, Mariangela Greco, Stefania Cresta, Daniela Piranda, Antony Holmes, Giulia Fabbri, Monica Messina, Andrea Rinaldi, **[[ Jiguang Wang]]**, Claudio Agostinelli, Pier Paolo Piccaluga, Marco Lucioni, Fabrizio Tabbò, Roberto Serra, Silvia Franceschetti, Clara Deambrogi, Giulia Daniele, Valter Gattei, Roberto Marasca, Fabio Facchetti, Luca Arcaini, Giorgio Inghirami, Francesco Bertoni, Stefano A Pileri, Silvia Deaglio, Robin Foà, Riccardo Dalla-Favera, Laura Pasqualucci, Raul Rabadan, Gianluca Gaidano.
~~ //The Journal of Experimental Medicine //, 209(9): 1537-1551, 2012.

{{image class="left" alt="EPL logo" url="images/users/wjg17.png" link=""}}
~~ Modularity optimization in community detection of complex networks.
~~ Xiang-Sun Zhang, Rui-Sheng Wang, Yong Wang, **[[ Jiguang Wang]]**, Yu-Qing Qiu, Lin Wang, and Luonan Chen.
~~ // Europhysics Letters//, 87: 38002, 2009.
~~ [[ ::PDF download::]] [[ :::This paper is selected as EPL Best of 2009 collection:::]]

{{image class="left" alt="JSSC logo" url="images/users/wjg18.png" link=""}}
~~ Remarks on network community properties
~~ **[[ Jiguang Wang]]**, Yuqing Qiu, Rui-Sheng Wang, Xiang-Sun Zhang.
~~ //Jrl Syst Sci & Complexity//, 21: 637-644, 2008.
~~ [[ ::PDF download::]] ---

=== {{color c="green" text="Books"}} ===

~-PhD Thesis: The Research on Molecular Network Models of Complex Disease, [[ Abstract]]

~-Contribution to [[ Encyclopedia of Systems Biology]]: Clustering methods, Co-expression, Edge ontology, Functional enrichment analysis, Gene ontology, Ontology analysis of biological networks, Partial correlation coefficient, Pearson correlation coefficient, Time-delay correlation


=== {{color c="green" text="Links"}} ===
~-[[ EXOTOME browser]] | [[ NOA Manual Page in NRNB]] | [[ NOA Cytoscape Plug-in in Cytoscape App Store]] | [[ NOA Webserver]]
~-[[ Rabadan Lab]] | [[ Basu Lab]] | [[ Wang Lab]] | [[ Xu's Digital Biology Lab]] | [[ Chen Lab]] | [[ Zhangroup]]
~-[[ ISCB ]] | [[ Bioinformatics Jobs]]
~-[[ Columbia University]] | [[ University of Missouri]] | [[ Beijing Institute of Genomics]] | [[ Academy of Mathematics & Systems Science]] | [[ Beijing Institute of Technology]] | [[ Cangzhou secondary high school]]
~- [[ Distinguishing Patterns of Tumor Evolution in Chronic Lymphocytic Leukemia]]
~- [[ Jiguang Wang named Irving Institute Precision Fellow]]
~- [[ Irving Institute for Clinical and Translational research]]
~- [[ Wang Genomic Lab @HKUST]]


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