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Guangxu Jin Ph.D.

Chinese Name: 金光旭

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Present Title & Affiliation

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Primary Appointment

Research Associate, Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX

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Office Address

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The Methodist Hospital Research Institute
6565 Fannin ST
B5-033
Houston, TX 77030
Office: +1 (713)441-7268
Cell: +1 (281)627-1455

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Education & Training

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Degree-Granting Education

2005.9 ~ 2008.7	Academy of Mathematics & Systems Science, CAS, Ph.D., Operational Research
2002.9 ~ 2005.7	Shenyang Normal University, M.S., Operational Research
1998.9 ~ 2002.7	Shenyang Normal University, B.S., Applied Mathematics

Postgraduate Traning

2007.12 ~ 2008.10	Exchange Student, The Methodist Hospital Research Institute & Weill Cornell Medical College
2008.10 ~ 2012.9	Postdoctoral Fellow, The Methodist Hospital Research Institute & Weill Cornell Medical College

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Professional Memberships

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American Association Cancer Research
Associate Member, 2011.2 - present

Intelligent Systems for Molecular Biology
Member, 2012.4 - present

American Chemical Society
Member, 2012.2 - present

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Research Interests

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• P2GWAS

• Drug repositioning

• Targeted therapy resistance

• Cell-Cell interaction modeling

• Next generation sequencing (Data analysis)

Vitae

• Curriculum Vitae （PDF）

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Selected Publications

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Peer-Reviewed Original Research Articles

1. Guangxu Jin and Stephen T.C. Wong (2013)
   Prioritizing drug repositioning methods into customized pipelines for efficient drug repositioning
   Drug Discovery Today. Under Revision.

1. Changhe Fu*, Guangxu Jin*, Junfeng Gao, Rui Zhu, Efren Ballesteros villagrana, Stephen T.C. Wong (2013)
   DrugMap Central (DMC), an on-line query and visualization tool to facilitate drug repositioning studies.
   Bioinformatics. 15;29(14):1834-6. DOI:10.1093/bioinformatics/btt279 *Co-first author.

1. Hong Zhao*, Guangxu Jin*, Kemi Cui , Ding Ren , Timothy Liu , Peikai Chen , Solomon Wong , Fuhai Li , Yubo Fan , Angel A. Rodriguez , Jenny C. Chang, Stephen T.C. Wong (2013)
   Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases.
   Cancer Research, DOI: 10.1158/0008-5472.CAN-12-4617. *Co-first author.

1. Fuhai Li, Zheng Yin, Guangxu Jin, Hong Zhao, Stephen Wong (2013)
   Bioimage Informatics for Systems Pharmacology.
   PLoS Comput Biol 9, e1003043.

1. Wang, L., Zhao, H., Cui, K., Yao, L., Ren, M., Hao, A., Smollen, P., Nie, F., Jin, G., Liu, Q. et al. (2012)
   Identification of novel small-molecule inhibitors of glioblastoma cell growth and invasion by high-throughput screening.
   Bioscience trends, 6, 192-200.

1. Wang, L., Liu, Q., Zhao, H., Cui, K., Yao, L., Nie, F., Jin, G., Hao, A. and Wong, S.T. (2013)
   Differential effects of low- and high-dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion.
   Journal of neuroscience research, 91, 128-137.

1. Fu, C., Deng, S., Jing, L., and Jin, G. (2012)
   Idenfication of Oncogenic Genes for Colon Adenocarcinoma from Genomics Data.
   IEEE systems biology, 6:263-266.

1. Guangxu Jin, Changhe Fu, Hong Zhao, Kemi Cui, Jenny Chang, Stephen T.C. Wong
   A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy.
   Cancer Res, 72:33-44, 2012.

1. Guangxu Jin, Hong Zhao, Xiaobo Zhou, Stephen T.C. Wong
   An enhanced Petri-net model to predict synergistic effects of pairwise drug combinations from gene microarray data.
   Bioinformatics, 27(13):i310-6, 2011.

1. Zhao H, Cui K, Nie F, Wang L, Brandl MB, Jin G, Li F, Mao Y, Xue Z, Rodriguez A, et al.,
   The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models.
   Breast Cancer Res Treat. 2011

1. Jin G, Cui K, Zhou X, Wong ST
   Unraveling the signal-transduction networks in cancer metastasis.
   IEEE Signal Proc Mag 26: 129-132, 2009.

1. Jin G, Zhou X, Cui K, Zhang XS, Chen L, Wong ST
   A cross-platform method for identifying candidate network biomarkers for prostate cancer.
   IET Syst Biol 3(6), 505-512, 2009.

1. Wang RS, Jin G, Zhang XS, Chen L
   Modeling post-transcriptional regulation activity of small non-coding RNAs in Escherichia coli.
   BMC Bioinformatics 10 Suppl 4: S6, 2009.

1. Jin G, Zhou X, Wang H, Zhao H, Cui K, Zhang XS, Chen L, Hazen SL, Li K, Wong ST
   The Knowledge-Integrated network biomarkers discovery for major adverse cardiac events.
   J Proteome Res 7(9): 4013-4021, 2008.

1. Jin G, Zhang S, Zhang XS, Chen L
   Hubs with network motifs organize modularity dynamically in the protein-protein interaction network of yeast.
   PLoS ONE 2(11): e1207, 2007.

1. Zhang S, Jin G, Zhang XS, Chen L (2007)
   Discovering functions and revealing mechanisms at molecular level from biological networks.
   Proteomics 7(16): 2856-2869, 2007.

Book Chapters

1. Jin G, Zhou X, Wang H, Wong ST
   The challenges in blood proteomic biomarker discovery.
   Applied Bioinformatics and Biostatistics in Cancer Research, Springer-Verlag New York Chapter 12, 2010.

Patent

1. Wong ST, Zhao H, Jin G (2012)
   Drug Repositioning Methods For Targeting Breast Tumor Initiating Cells.
   US Patent 20,120,296,090

DrugMap Central database

• http://r2d2drug.org/DMC.aspx

Last updated: 5/15/13

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• 2013-10-10 04:28:03
• Owner: GuangxuJin
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