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Guangxu Jin Ph.D.
Chinese Name: 金光旭Present Title & Affiliation
Primary Appointment
Research Associate, Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX
Office Address
The Methodist Hospital Research Institute
6565 Fannin ST
B5-033
Houston, TX 77030
Office: +1 (713)441-7268
Cell: +1 (281)627-1455
Education & Training
Degree-Granting Education
2005.9 ~ 2008.7 | Academy of Mathematics & Systems Science, CAS, Ph.D., Operational Research |
2002.9 ~ 2005.7 | Shenyang Normal University, M.S., Operational Research |
1998.9 ~ 2002.7 | Shenyang Normal University, B.S., Applied Mathematics |
Postgraduate Traning
2007.12 ~ 2008.10 | Exchange Student, The Methodist Hospital Research Institute & Weill Cornell Medical College |
2008.10 ~ 2012.9 | Postdoctoral Fellow, The Methodist Hospital Research Institute & Weill Cornell Medical College |
Professional Memberships
American Association Cancer Research
Associate Member, 2011.2 - present
Intelligent Systems for Molecular Biology
Member, 2012.4 - present
American Chemical Society
Member, 2012.2 - present
Research Interests
- P2GWAS
Personalized medicine
- Drug repositioning
Computational modeling
Database construction
Software development
- Targeted therapy resistance
Gefitinib
Lapatinib
- Cell-Cell interaction modeling
Lung Cancer
- Next generation sequencing (Data analysis)
Pipelines for RNA-Seq data analysis
Pipelines for mutation detection
Vitae
Selected Publications
Peer-Reviewed Original Research Articles
- Guangxu Jin and Stephen T.C. Wong (2013)
Prioritizing drug repositioning methods into customized pipelines for efficient drug repositioning
Drug Discovery Today. Under Revision.
- Changhe Fu*, Guangxu Jin*, Junfeng Gao, Rui Zhu, Efren Ballesteros villagrana, Stephen T.C. Wong (2013)
DrugMap Central (DMC), an on-line query and visualization tool to facilitate drug repositioning studies.
Bioinformatics. 15;29(14):1834-6. DOI:10.1093/bioinformatics/btt279 *Co-first author.
- Hong Zhao*, Guangxu Jin*, Kemi Cui , Ding Ren , Timothy Liu , Peikai Chen , Solomon Wong , Fuhai Li , Yubo Fan , Angel A. Rodriguez , Jenny C. Chang, Stephen T.C. Wong (2013)
Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases.
Cancer Research, DOI: 10.1158/0008-5472.CAN-12-4617. *Co-first author.
- Fuhai Li, Zheng Yin, Guangxu Jin, Hong Zhao, Stephen Wong (2013)
Bioimage Informatics for Systems Pharmacology.
PLoS Comput Biol 9, e1003043.
- Wang, L., Zhao, H., Cui, K., Yao, L., Ren, M., Hao, A., Smollen, P., Nie, F., Jin, G., Liu, Q. et al. (2012)
Identification of novel small-molecule inhibitors of glioblastoma cell growth and invasion by high-throughput screening.
Bioscience trends, 6, 192-200.
- Wang, L., Liu, Q., Zhao, H., Cui, K., Yao, L., Nie, F., Jin, G., Hao, A. and Wong, S.T. (2013)
Differential effects of low- and high-dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion.
Journal of neuroscience research, 91, 128-137.
- Fu, C., Deng, S., Jing, L., and Jin, G. (2012)
Idenfication of Oncogenic Genes for Colon Adenocarcinoma from Genomics Data.
IEEE systems biology, 6:263-266.
- Guangxu Jin, Changhe Fu, Hong Zhao, Kemi Cui, Jenny Chang, Stephen T.C. Wong
A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy.
Cancer Res, 72:33-44, 2012.
- Guangxu Jin, Hong Zhao, Xiaobo Zhou, Stephen T.C. Wong
An enhanced Petri-net model to predict synergistic effects of pairwise drug combinations from gene microarray data.
Bioinformatics, 27(13):i310-6, 2011.
- Zhao H, Cui K, Nie F, Wang L, Brandl MB, Jin G, Li F, Mao Y, Xue Z, Rodriguez A, et al.,
The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models.
Breast Cancer Res Treat. 2011
- Jin G, Cui K, Zhou X, Wong ST
Unraveling the signal-transduction networks in cancer metastasis.
IEEE Signal Proc Mag 26: 129-132, 2009.
- Jin G, Zhou X, Cui K, Zhang XS, Chen L, Wong ST
A cross-platform method for identifying candidate network biomarkers for prostate cancer.
IET Syst Biol 3(6), 505-512, 2009.
- Wang RS, Jin G, Zhang XS, Chen L
Modeling post-transcriptional regulation activity of small non-coding RNAs in Escherichia coli.
BMC Bioinformatics 10 Suppl 4: S6, 2009.
- Jin G, Zhou X, Wang H, Zhao H, Cui K, Zhang XS, Chen L, Hazen SL, Li K, Wong ST
The Knowledge-Integrated network biomarkers discovery for major adverse cardiac events.
J Proteome Res 7(9): 4013-4021, 2008.
- Jin G, Zhang S, Zhang XS, Chen L
Hubs with network motifs organize modularity dynamically in the protein-protein interaction network of yeast.
PLoS ONE 2(11): e1207, 2007.
- Zhang S, Jin G, Zhang XS, Chen L (2007)
Discovering functions and revealing mechanisms at molecular level from biological networks.
Proteomics 7(16): 2856-2869, 2007.
Book Chapters
- Jin G, Zhou X, Wang H, Wong ST
The challenges in blood proteomic biomarker discovery.
Applied Bioinformatics and Biostatistics in Cancer Research, Springer-Verlag New York Chapter 12, 2010.
Patent
- Wong ST, Zhao H, Jin G (2012)
Drug Repositioning Methods For Targeting Breast Tumor Initiating Cells.
US Patent 20,120,296,090
DrugMap Central database
File | Last modified | Size |
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AACR-hong.pdf | 2009-03-31 07:44 | 18Kb |
AACR-kemi.pdf | 2009-03-31 07:44 | 18Kb |
Guangxu Jin_20131015_1.pdf | 2013-10-16 04:43 | 94Kb |
Guangxu Jin_20140609.pdf | 2014-07-01 21:12 | 119Kb |
GuangxuJin_20131015_1.pdf | 2013-10-16 04:45 | 94Kb |
Guangxu_Jin_CV_063012.pdf | 2012-06-01 02:35 | 124Kb |
IEEESignalProcMag.pdf | 2009-10-02 23:05 | 869Kb |
Plosone.pdf | 2007-12-23 15:03 | 1Mb |
Proteomics.pdf | 2008-12-23 06:51 | 407Kb |
pr8002886.pdf | 2008-12-23 06:53 | 4Mb |
Last updated: 5/15/13