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Guangxu Jin Ph.D.

Chinese Name: 金光旭

Present Title & Affiliation


Primary Appointment

Instructor and Research Associate, Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX


Office Address


The Methodist Hospital Research Institute
6565 Fannin ST
B5-033
Houston, TX 77030
Office: +1 (713)441-7268
Cell: +1 (281)627-1455


Education & Training



Degree-Granting Education

2005.9 ~ 2008.7Academy of Mathematics & Systems Science, CAS, Ph.D., Operational Research
2002.9 ~ 2005.7Shenyang Normal University, M.S., Operational Research
1998.9 ~ 2002.7Shenyang Normal University, B.S., Applied Mathematics

Postgraduate Traning


2007.12 ~ 2008.10Exchange Student, The Methodist Hospital Research Institute & Weill Cornell Medical College
2008.10 ~ 2012.9Postdoctoral Fellow, The Methodist Hospital Research Institute & Weill Cornell Medical College


Professional Memberships


American Association Cancer Research
Associate Member, 2011.2 - present

Intelligent Systems for Molecular Biology
Member, 2012.4 - present

American Chemical Society
Member, 2012.2 - present


Research Interests



Vitae




Selected Publications



Peer-Reviewed Original Research Articles

  1. Guangxu Jin and Stephen T.C. Wong (2013) Invited review
    Enhanced Petri Net: Elucidating the Pathway-Level Mechanism of Targeted-Therapy Drugs
    Information Technology. Under Revision.
  2. Guangxu Jin and Stephen T.C. Wong (2013) Invited review
    Toward better drug repositioning: Prioritizing and integrating existing methods into efficient pipelines
    Drug Discovery Today. DOI: 10.1016/j.drudis.2013.11.005.
  3. Changhe Fu*, Guangxu Jin*, Junfeng Gao, Rui Zhu, Efren Ballesteros villagrana, Stephen T.C. Wong (2013)
    DrugMap Central (DMC), an on-line query and visualization tool to facilitate drug repositioning studies.
    Bioinformatics. 15;29(14):1834-6. DOI:10.1093/bioinformatics/btt279 *Co-first author. GuangxuJin
  4. Hong Zhao*, Guangxu Jin*, Kemi Cui , Ding Ren , Timothy Liu , Peikai Chen , Solomon Wong , Fuhai Li , Yubo Fan , Angel A. Rodriguez , Jenny C. Chang, Stephen T.C. Wong (2013)
    Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases.
    Cancer Research, DOI: 10.1158/0008-5472.CAN-12-4617. *Co-first author. Cover paper and cover image.
  5. Fuhai Li, Zheng Yin, Guangxu Jin, Hong Zhao, Stephen Wong (2013)
    Bioimage Informatics for Systems Pharmacology.
    PLoS Comput Biol 9, e1003043.
  6. Wang, L., Zhao, H., Cui, K., Yao, L., Ren, M., Hao, A., Smollen, P., Nie, F., Jin, G., Liu, Q. et al. (2012)
    Identification of novel small-molecule inhibitors of glioblastoma cell growth and invasion by high-throughput screening.
    Bioscience trends, 6, 192-200.
  7. Wang, L., Liu, Q., Zhao, H., Cui, K., Yao, L., Nie, F., Jin, G., Hao, A. and Wong, S.T. (2013)
    Differential effects of low- and high-dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion.
    Journal of neuroscience research, 91, 128-137.
  8. Fu, C., Deng, S., Jing, L., and Jin, G. (2012)
    Idenfication of Oncogenic Genes for Colon Adenocarcinoma from Genomics Data.
    IEEE systems biology, 6:263-266.
  9. Guangxu Jin, Changhe Fu, Hong Zhao, Kemi Cui, Jenny Chang, Stephen T.C. Wong
    A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy.
    Cancer Res, 72:33-44, 2012.
  10. Guangxu Jin, Hong Zhao, Xiaobo Zhou, Stephen T.C. Wong
    An enhanced Petri-net model to predict synergistic effects of pairwise drug combinations from gene microarray data.
    Bioinformatics, 27(13):i310-6, 2011.
  11. Zhao H, Cui K, Nie F, Wang L, Brandl MB, Jin G, Li F, Mao Y, Xue Z, Rodriguez A, et al.,
    The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models.
    Breast Cancer Res Treat. 2011
  12. Jin G, Cui K, Zhou X, Wong ST
    Unraveling the signal-transduction networks in cancer metastasis.
    IEEE Signal Proc Mag 26: 129-132, 2009.
  13. Jin G, Zhou X, Cui K, Zhang XS, Chen L, Wong ST
    A cross-platform method for identifying candidate network biomarkers for prostate cancer.
    IET Syst Biol 3(6), 505-512, 2009.
  14. Wang RS, Jin G, Zhang XS, Chen L
    Modeling post-transcriptional regulation activity of small non-coding RNAs in Escherichia coli.
    BMC Bioinformatics 10 Suppl 4: S6, 2009.
  15. Jin G, Zhou X, Wang H, Zhao H, Cui K, Zhang XS, Chen L, Hazen SL, Li K, Wong ST
    The Knowledge-Integrated network biomarkers discovery for major adverse cardiac events.
    J Proteome Res 7(9): 4013-4021, 2008.
  16. Jin G, Zhang S, Zhang XS, Chen L
    Hubs with network motifs organize modularity dynamically in the protein-protein interaction network of yeast.
    PLoS ONE 2(11): e1207, 2007.
  17. Zhang S, Jin G, Zhang XS, Chen L (2007)
    Discovering functions and revealing mechanisms at molecular level from biological networks.
    Proteomics 7(16): 2856-2869, 2007.

Book Chapters

  1. Jin G, Wong ST
    Proteomics Based Theranostics
    Cancer Theranostics, Elsevier, 2013, In Press.
  2. Jin G, Encyclopedia of Systems Biology, Springer, New York, 2013
    Chapters: Single-Input Module (1954-1954), Dense Overlapping Regulons (560-560), Feed Forward Loop (737-738), Network Topology Motif (1523-1524), Network Motifs of Gene Regulatory Networks (1521-1523)
  3. Jin G, Zhou X, Wang H, Wong ST
    The challenges in blood proteomic biomarker discovery.
    Applied Bioinformatics and Biostatistics in Cancer Research, Springer-Verlag New York Chapter 12, 2010.

Patent

  1. Wong ST, Zhao H, Jin G (2012)
    Drug Repositioning Methods For Targeting Breast Tumor Initiating Cells.
    US Patent 20,120,296,090

DrugMap Central database


Last updated: 10/15/13
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