Guangxujin

Guangxu Jin, Ph.D.

Assistant Professor, Wake Forest School of Medicine,
Department of Radiology, Wake Forest Baptist Medical Center
Comprehensive cancer center, Wake Forest Baptist Medical Center

MRI 2nd FL
Medical Center Blvd
Winston-Salem, NC 27157
Office: +1 (336)716-6977
Cell: +1 (281)627-1455


Education & Training

2012.10 ~ 2014.2Instructor and Research Associate The Methodist Hospital Research Institute & Weill Cornell Medical College
2008.10 ~ 2012.9Postdoctoral Fellow The Methodist Hospital Research Institute & Weill Cornell Medical College
2007.12 ~ 2008.10Exchange Student The Methodist Hospital Research Institute & Weill Cornell Medical College
2005.9 ~ 2008.7Ph.D., BioinformaticsAcademy of Mathematics & Systems Science, CAS
2002.9 ~ 2005.7M.S., Operational ResearchShenyang Normal University
1998.9 ~ 2002.7B.S., Applied MathematicsShenyang Normal University

Professional Memberships

American Association Cancer Research
Member, 2011.2 - present

Research Interests
Previous: Cancer genomics, bioinformatics modeling
Tumor recurrence is a major issue for many cancer types, such as glioblastoma multiforme (GBM) patients after receiving Temador treatments. However, the related molecular biology is not easy to be understood. It is because of the complexity of transcriptional events, which may be a mixture of epigenetic regulation and genetic variation on function regions (e.g., enhancers and promoters). Recurrence or drug resistance is stage-specific. My research interest is on the patient-specific analysis by considering the variations from transcriptional, epigentic, and genetic variations. By applying to different stages of a patient, the failure of treatment can be explained by the identified comprehensive mechanisms, such as the regulation of a methylation on a new gene isoform or a function lost caused by a mutation in the CDS. The identified epigenetic regulation and genetic variation will be validated by CRISPR and TALE-TET1 genome editing techniques.

Selected Publications
Research Articles
  1. L Liu, G Jin*, X Zhou* (2015)
    Modeling the relationship of epigenetic modifications to transcription factor binding
    Nucleic acids research 43 (8), 3873-3885. *co-corresponding author
  2. Choi DS, Blanco E, Kim YS, Rodriguez AA, Zhao H, Huang TH, Chen CL, Jin G, Landis MD, Burey LA, Qian W, Granados SM, Dave B, Wong HH, Ferrari M, Wong ST, Chang JC. (2014)
    Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1.
    Stem cells. doi: 10.1002/stem.1746.
  3. Guangxu Jin and Stephen T.C. Wong (2014) Invited review
    Enhanced Petri Net: Elucidating the Pathway-Level Mechanism of Targeted-Therapy Drugs
    Information Technology. 56(2): 67-75.
  4. Guangxu Jin and Stephen T.C. Wong (2014) Invited review
    Toward better drug repositioning: Prioritizing and integrating existing methods into efficient pipelines
    Drug Discovery Today. 19(5); 637-644.
  5. Timothy Liu, Ding Ren, Xiaoping Zhu, Zheng Yin, Guangxu Jin, Zhen Zhao, Daniel Robinson, Xuping Li, Kelvin Wong, Kemi Cui, Hong Zhao, Stephen TC Wong (2013)
    Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform
    Scientific Report 3: 3467.
  6. Changhe Fu*, Guangxu Jin*, Junfeng Gao, Rui Zhu, Efren Ballesteros villagrana, Stephen T.C. Wong (2013)
    DrugMap Central (DMC), an on-line query and visualization tool to facilitate drug repositioning studies.
    Bioinformatics. 15;29(14):1834-6. *Co-first author. GuangxuJin
  7. Hong Zhao*, Guangxu Jin*, Kemi Cui , Ding Ren , Timothy Liu , Peikai Chen , Solomon Wong , Fuhai Li , Yubo Fan , Angel A. Rodriguez , Jenny C. Chang, Stephen T.C. Wong (2013)
    Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases.
    Cancer Research, DOI: 10.1158/0008-5472.CAN-12-4617. *Co-first author. Cover paper and cover image.
  8. Fuhai Li, Zheng Yin, Guangxu Jin, Hong Zhao, Stephen Wong (2013)
    Bioimage Informatics for Systems Pharmacology.
    PLoS Comput Biol 9, e1003043.
  9. Wang, L., Zhao, H., Cui, K., Yao, L., Ren, M., Hao, A., Smollen, P., Nie, F., Jin, G., Liu, Q. et al. (2012)
    Identification of novel small-molecule inhibitors of glioblastoma cell growth and invasion by high-throughput screening.
    Bioscience trends, 6, 192-200.
  10. Wang, L., Liu, Q., Zhao, H., Cui, K., Yao, L., Nie, F., Jin, G., Hao, A. and Wong, S.T. (2013)
    Differential effects of low- and high-dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion.
    Journal of neuroscience research, 91, 128-137.
  11. Fu, C., Deng, S., Jing, L., and Jin, G. (2012)
    Idenfication of Oncogenic Genes for Colon Adenocarcinoma from Genomics Data.
    IEEE systems biology, 6:263-266.
  12. Guangxu Jin, Changhe Fu, Hong Zhao, Kemi Cui, Jenny Chang, Stephen T.C. Wong
    A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy.
    Cancer Res, 72:33-44, 2012.
  13. Guangxu Jin, Hong Zhao, Xiaobo Zhou, Stephen T.C. Wong
    An enhanced Petri-net model to predict synergistic effects of pairwise drug combinations from gene microarray data.
    Bioinformatics, 27(13):i310-6, 2011.
  14. Zhao H, Cui K, Nie F, Wang L, Brandl MB, Jin G, Li F, Mao Y, Xue Z, Rodriguez A, et al.,
    The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models.
    Breast Cancer Res Treat. 2011
  15. Jin G, Cui K, Zhou X, Wong ST
    Unraveling the signal-transduction networks in cancer metastasis.
    IEEE Signal Proc Mag 26: 129-132, 2009.
  16. Jin G, Zhou X, Cui K, Zhang XS, Chen L, Wong ST
    A cross-platform method for identifying candidate network biomarkers for prostate cancer.
    IET Syst Biol 3(6), 505-512, 2009.
  17. Wang RS, Jin G, Zhang XS, Chen L
    Modeling post-transcriptional regulation activity of small non-coding RNAs in Escherichia coli.
    BMC Bioinformatics 10 Suppl 4: S6, 2009.
  18. Jin G, Zhou X, Wang H, Zhao H, Cui K, Zhang XS, Chen L, Hazen SL, Li K, Wong ST
    The Knowledge-Integrated network biomarkers discovery for major adverse cardiac events.
    J Proteome Res 7(9): 4013-4021, 2008.
  19. Jin G, Zhang S, Zhang XS, Chen L
    Hubs with network motifs organize modularity dynamically in the protein-protein interaction network of yeast.
    PLoS ONE 2(11): e1207, 2007.
  20. Zhang S, Jin G, Zhang XS, Chen L (2007)
    Discovering functions and revealing mechanisms at molecular level from biological networks.
    Proteomics 7(16): 2856-2869, 2007.
Book Chapters
  1. Jin G, Wong ST
    Proteomics Based Theranostics
    Cancer Theranostics, Elsevier, 2014.
  2. Jin G, Encyclopedia of Systems Biology, Springer, New York, 2013
    Chapters: Single-Input Module (1954-1954), Dense Overlapping Regulons (560-560), Feed Forward Loop (737-738), Network Topology Motif (1523-1524), Network Motifs of Gene Regulatory Networks (1521-1523)
  3. Jin G, Zhou X, Wang H, Wong ST
    The challenges in blood proteomic biomarker discovery.
    Applied Bioinformatics and Biostatistics in Cancer Research, Springer-Verlag New York Chapter 12, 2010.
Patent
  1. Wong ST, Zhao H, Jin G (2012)
    Drug Repositioning Methods For Targeting Breast Tumor Initiating Cells.
    US Patent 20,120,296,090

database
Last updated: 08/11/15
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